ID A0A3B5BIN7_9TELE Unreviewed; 1349 AA.
AC A0A3B5BIN7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRD {ECO:0000313|Ensembl:ENSSPAP00000031174.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000031174.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000031174.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR Ensembl; ENSSPAT00000031674.1; ENSSPAP00000031174.1; ENSSPAG00000023367.1.
DR GeneTree; ENSGT00940000153617; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 703..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..86
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 94..176
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 183..273
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 278..374
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 376..455
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 457..543
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 794..1049
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 969..1040
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1081..1340
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1258..1331
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 263..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1349 AA; 152254 MW; 7355D168977C4C6F CRC64;
MGPQLKVVER TRTATMLCAA SGNPDPDISW FKDFLPVNTT NNNGRIKQLR SGALQIEQSE
ESDQGKYECV ATNNDGTRYS APANLYVRVR RVPPRFSIPP TDNEIMPGGS VNITCVAVGS
PMPYVKWMLG AEDLTPEDDM PIGRNVLELT DVRQSANYTC VAMSTLGVIE AVAQITVKAL
PKAPGIPVVT ERTATSITLT WDSGNPEPVS YYIIQHKSKY SEDLYKEIDG VATTRYSVGG
LSPYSDYEFR VVAVNNIGRG PPSESIEAKT AEQAPSTAPR QVRGHMMSAT TAVIQWDEPE
EANGQIMGYR VYYTMDSAQH VNLWEKQIVR GSNFVTIQGL IPNKTYYIKV LAYTSVGDGP
LSPDLQIIAK TGVPSQPTDF KGEAKSETSI LLSWVAPADT NNLSSPQKRI SFEPTTTYLL
KDLKPFTTYT FRLAARSKHG VGAYTSEISA ETPQTLFAKN FHVRAAMKTS VLLTWEIPDT
YNPAQPFTIL YDNGQSVEVD GKLTQKLITG LQPETQYSFL LTNRGNSAGG LQHRVSTMTA
PDILRTKPYL ISKTNSDGMV TVELPTVQTS ERVRGYYIVV VPLKKQRTGK FFKPWDNPDE
MNLEELLKEI NRTSRGLRFQ RQAEPRAYIA AYYKDLPKDF TLGDGKMYGD FENKQLETGL
EYIFFVLAVL EMSENIMYAT SPYSDPVVSA GIPPQPVIDE EEGLIWVVGP VLAVVFIICI
VIAILLYKRK RAESEARKGS LPNSKEMPLH HPTDPVELRR LNFQTPGMAS HPPIPVMDLA
DHLERLKAND NLKFSQEYES IDPGQQFTWE HSNLEVNKPK NRYANVIAYD HSRVLLSAID
GIPGSDYINA NYIDGYRKQN AYIATQGSLP ETFGEFWRMI WEQRSAIVVM MTKLEERSRV
KCDQYWPTRG TETYGLIQVT LLDTVELATY CVRTFALFKN GSSEKREVRQ FQFTAWPDHG
VPEHPTPFLA FLRRVKACNP PDAGPMVVHC SAGVGRTGCF IVIDAMLERI KHEKTVDIYG
HVTLMRAQRN YMVQTEDQYV FIHDALQEAV NCGTTEVPAR NLYAYIQKLT QIEGGENVTG
MELEFKRLAN TKAHTSRFIS ANLPCNKFKN RLVNIMPYES TRVCLQPIRG VEGSDYINAS
FIDGYRQQKA YIATQGPLAE TTEDFWRMLW EHNSTIVVML TKLREMGREK CHQYWPAERS
ARYQYFVVDP MAEYNMPQYI LREFKVTDAR DGQSRTVRQF QFTDWPEQGV PKSGEGFIDF
IGQVHKTKEQ FGQDGPISVH CSAGVGRTGV FITLSIVLER MRYEGVVDIF QTVKMLRTQR
PAMVQTEDQY QFCYRAGLEY LGSFDHYAT
//
