ID A0A3B5JU77_TAKRU Unreviewed; 1098 AA.
AC A0A3B5JU77;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Protein 4.1 {ECO:0000256|ARBA:ARBA00023658};
DE AltName: Full=Band 4.1 {ECO:0000256|ARBA:ARBA00030419};
DE AltName: Full=Erythrocyte membrane protein band 4.1 {ECO:0000256|ARBA:ARBA00032586};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000047852.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000047852.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000047852.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3B5JU77; -.
DR STRING; 31033.ENSTRUP00000075376; -.
DR Ensembl; ENSTRUT00000057989.2; ENSTRUP00000047852.2; ENSTRUG00000016155.3.
DR GeneTree; ENSGT00940000157833; -.
DR Proteomes; UP000005226; Chromosome 7.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13184; FERM_C_4_1_family; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR008379; Band_4.1_C.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR007477; SAB_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF12; PROTEIN 4.1; 1.
DR Pfam; PF05902; 4_1_CTD; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF04382; SAB; 1.
DR PIRSF; PIRSF002304; Membrane_skeletal_4_1; 5.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 503..784
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1008..1098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1091
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1098 AA; 125130 MW; 5BA6FD9C4C69FCA6 CRC64;
MTTEASAVSD ADTEGKQKAS AAAEPETENK TPEAATSEPE GEQTNKKVEE PGPADVAASL
EEEQLKPRTR TSAGKGLSRL FSSFLKRRSQ CSEDDGPEAE KVKEEKEHAD EKADDREEEG
KSEQKEAKVD EEKAEVKDKE EKEQKEDNKK EEEKIEKKGS KKKKKEAKKK AEKKDEEKVN
EAEVKKEEEN VKKEAEKTDD KAEKTVEKEE EKVERKEDPK KETCDEKEKG SEEGKKETKE
EENIDKKVAK KKEKEDKIKK KEEEKAKRKA EEEDRIKKKE EERAKKREEE KAREAEKAKK
KEEEKAKKKE EEEKAKEEKT KKKGEEKTKK KEDEKLKDSK KKEEEKPKEV KKEKEKEVEK
PEEKKEEEKG KKKDKGKSKE KKNVKEVEGL SEEQLKAPIA APEPELKTEP DMEQAPDQRS
VSSAEMQQPP QEEQKEAERE EPKEEAEIQP EEGEKKEEEP AEKEKEDQGE EKVQEEGKEK
AVKDKKAEKK SEEAKGSKRQ KTIQCKVIML DDSQFECELD KHAKGQELLT KVCDHINLLE
KDYFGLANWD TPTNKTWLET TKEIRKQVPG AVYEFTFSVK FYPPDPAQLS EDLTRYYLCL
QLRKDIMRGA LPCSFVTLSL LGSYVAQSEL GEYDPEVHGT DYVKDLSLAP GQSKELEEKV
MELHRTYRSM SPAQADMLFL ENAKKLAMYG VDLHQAKDLD GVDITLGVCS SGLMVYKDKL
RINRFPWPKV LKISYKRSSF FIKIRASEQE QYESTIGFKL PHYKASKKLW KVCVEHHTFF
RVQTVDPPSS RRFPVLGSKF RYSGRTQVQT RQASSMIDRP APRFTRSASK RLSRNLDGVV
VTQRGTRPVS APVFSQTALA EAGIPMAPFD QPQTSTPIKT TRKEERKLEV TVEAVEPSKI
ESVGEVKTAE WRDQREIHSS LVSTINGDSQ HESETSTEVV RLRKKRKKIE GDSIYIRHSL
LMLEDFDKPN EELVKHHASI SELKRNFMEA VPEPRPSEWE KRLSTHSPFR NLGINGQPLS
GADGASDEGT DRDSTTMSSS TSVTSETTSG TTVTTTTTHI SKVVKSGSTE TRVEKRIIIT
ADSDADQDKG KDGGSSAL
//