ID A0A3B5JV74_TAKRU Unreviewed; 364 AA.
AC A0A3B5JV74;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF {ECO:0000256|PIRNR:PIRNR037866};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000048403.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000048403.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000048403.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Scaffold protein that connects plasma membrane proteins with
CC members of the ezrin/moesin/radixin family and thereby helps to link
CC them to the actin cytoskeleton and to regulate their surface
CC expression. {ECO:0000256|PIRNR:PIRNR037866}.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004184, ECO:0000256|PIRNR:PIRNR037866};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184,
CC ECO:0000256|PIRNR:PIRNR037866}.
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DR AlphaFoldDB; A0A3B5JV74; -.
DR STRING; 31033.ENSTRUP00000048403; -.
DR Ensembl; ENSTRUT00000049909.2; ENSTRUP00000048403.2; ENSTRUG00000024458.2.
DR GeneTree; ENSGT00950000182849; -.
DR InParanoid; A0A3B5JV74; -.
DR OMA; VTRICEV; -.
DR Proteomes; UP000005226; Chromosome 17.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 2.
DR Gene3D; 2.30.42.10; -; 2.
DR InterPro; IPR015098; EBP50_C.
DR InterPro; IPR017300; NHERF-1/NHERF-2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14191:SF4; NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF2; 1.
DR PANTHER; PTHR14191; PDZ DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF09007; EBP50_C; 1.
DR Pfam; PF00595; PDZ; 2.
DR PIRSF; PIRSF037866; EBP50; 1.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR PROSITE; PS50106; PDZ; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|PIRNR:PIRNR037866};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 9..89
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 172..252
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 112..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 364 AA; 39596 MW; 1AABC87C3AC063AF CRC64;
MEGELRPRLC FLTKGGRGYG FHLHGERNKG GQFIRTVEPG SSADMAGLRP GDRVVEVNGE
NVEMEPHYQV VNRILEVPHR TKLLVVDRDT DEYLHVNGLA CTEALAVVMG TLSPRPSPGP
TPSTSPLPRG ISPKLRQLLS SAADSPTSMD AQIEVKQSSE TSSPPDKLVP RLCHMVKGER
GYGFNLHNNK AKRGQFVRAV DRGSPADDAD LRPGDRLIEV NGVSVDGLRH SEVVALIKAG
GEEVRLLVVD LETDELFLRL GLPPNTSPGN GEVYADASVT NSEPPTPSPT VGLPATEPPT
INITVTDSTV PDEDDRRISD PFIESGLRLS PTAAEARQKV ITSRIKKRAP PMDWSKRQEI
FSNF
//
