ID A0A3B5JW14_TAKRU Unreviewed; 581 AA.
AC A0A3B5JW14;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Frizzled class receptor 8 {ECO:0000313|Ensembl:ENSTRUP00000048893.2};
GN Name=fzd8 {ECO:0000313|Ensembl:ENSTRUP00000048893.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000048893.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000048893.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000048893.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR RefSeq; XP_003967887.1; XM_003967838.2.
DR AlphaFoldDB; A0A3B5JW14; -.
DR STRING; 31033.ENSTRUP00000048893; -.
DR Ensembl; ENSTRUT00000029333.3; ENSTRUP00000048893.2; ENSTRUG00000011564.3.
DR GeneID; 101078921; -.
DR KEGG; tru:101078921; -.
DR CTD; 58073; -.
DR GeneTree; ENSGT00940000161191; -.
DR InParanoid; A0A3B5JW14; -.
DR OMA; SWPERMA; -.
DR OrthoDB; 5483535at2759; -.
DR Proteomes; UP000005226; Chromosome 10.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0060898; P:eye field cell fate commitment involved in camera-type eye formation; IEA:Ensembl.
DR GO; GO:0021879; P:forebrain neuron differentiation; IEA:Ensembl.
DR GO; GO:0021529; P:spinal cord oligodendrocyte cell differentiation; IEA:Ensembl.
DR GO; GO:0021531; P:spinal cord radial glial cell differentiation; IEA:Ensembl.
DR CDD; cd15250; 7tmF_FZD8; 1.
DR CDD; cd07461; CRD_FZ8; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR041776; FZ8_CRD.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF146; FRIZZLED 8A PROTEIN-RELATED; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..581
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025675132"
FT TRANSMEM 240..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..144
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 239..533
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 152..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 28..89
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 36..82
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 73..111
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 100..141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 104..128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 581 AA; 65442 MW; C2428F35A5AAD487 CRC64;
MDLFGIYLSL SLALLPRSSC TTAKEITCQE IAVPLCKGIG YNYTYMPNQF NHDTQDEAGL
EVHQFWPLVE IQCSPDLKFF LCSMYTPICL EDYKKPLPPC RSVCERARAG CAPLMRQYGF
PWPDRMRCDL LPVQGNPDTL CMDYNRTDST TVSPVLSKPT NYPGKGHNVP KNKPTRTGSP
GKYKPPSAPC EPGCKCLEPM VPVNTDRHPL YNRVKTGQIN NCAMPCHNPY FTHDERAFTA
FWIGLWSVLC FVSTFATVAT FLIDMERFKY PERPIIFLSA CYMFVSIGYI VRLIAGHEKV
ACSREFDVEH IHYDTTGPAL CTVVFLLIYF FGMASSIWWV ILSLTWFLAA GMKWGNEAIA
SYSQYFHLAA WLIPSMKSIA VLALSSVDGD SVAGICYVGN QNLDNLRGFV LAPLVIYLFI
GTMFLLAGFV SLFRIRSVIK QGGTKTDKLE KLMIRIGIFT VLYTVPATVI VACYFYEQHN
RQSWEITHNC SDCLLERDRK SPDYAVFMLK YFMCLLVGIT SGVWIWSGKT VDSWRTFCTR
CCWGSKGTSG SMYSDVSTGL TWRSGTASSV SCPKQMPLSQ V
//