ID   A0A3B5JX04_TAKRU        Unreviewed;       185 AA.
AC   A0A3B5JX04;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Interleukin-18 {ECO:0000256|PIRNR:PIRNR015162};
DE            Short=IL-18 {ECO:0000256|PIRNR:PIRNR015162};
GN   Name=il-18 {ECO:0000313|Ensembl:ENSTRUP00000049434.2};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000049434.2, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000049434.2, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000049434.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR015162}.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC       {ECO:0000256|PIRNR:PIRNR015162}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3B5JX04; -.
DR   Ensembl; ENSTRUT00000051496.2; ENSTRUP00000049434.2; ENSTRUG00000031110.1.
DR   GeneTree; ENSGT00390000001053; -.
DR   InParanoid; A0A3B5JX04; -.
DR   OMA; RECHPER; -.
DR   Proteomes; UP000005226; Chromosome 11.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.80.10.50; -; 1.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR008996; IL1/FGF.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   SUPFAM; SSF50353; Cytokine; 1.
PE   3: Inferred from homology;
KW   Cytokine {ECO:0000256|PIRNR:PIRNR015162};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Secreted {ECO:0000256|PIRNR:PIRNR015162}.
SQ   SEQUENCE   185 AA;  21643 MW;  1096A04F1DCE5CE9 CRC64;
     MAANNGNFVT FLHATETAFY FEELDKDGFL YKSDFQKWIK SKDNKFLILN ESAEFQCQNL
     SIQEQEYYPE NKPHVCVYKN SDKMGKMGVI LYTCKDQKKV VLCCSDKLEI HPVEMDISHD
     IAEKAHKALF YLERITEGCY LLESSLYPSM FLAFEPDSNN QTLNKVILRR KKYDEVDETC
     YVTMS
//