ID A0A3B5JZG6_TAKRU Unreviewed; 1378 AA.
AC A0A3B5JZG6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Insulin receptor substrate 2-B-like {ECO:0000313|Ensembl:ENSTRUP00000050555.2};
GN Name=LOC101074788 {ECO:0000313|Ensembl:ENSTRUP00000050555.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000050555.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000050555.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000050555.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 31033.ENSTRUP00000050555; -.
DR Ensembl; ENSTRUT00000056522.2; ENSTRUP00000050555.2; ENSTRUG00000022256.2.
DR GeneTree; ENSGT00940000160883; -.
DR InParanoid; A0A3B5JZG6; -.
DR OMA; DDVRKCG; -.
DR OrthoDB; 4212441at2759; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF2; INSULIN RECEPTOR SUBSTRATE 4; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 154..273
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 298..402
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 19..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1115..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1333..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..827
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..961
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1027
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1075
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1337..1351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1378 AA; 146109 MW; AA260D45621C7D6D CRC64;
MANFTNYQEG KAAMLMVETQ QRDVGTKPAA ASANGDGSVG EPPSPLINIG GGGGGGGGGT
RFHQQLPPSN QFHNQLFSYQ QPPKDQQHQH YQLPPQQHIS EENTAGSPGR KPSSSSLSQV
HAAEDPAACP TTSRSGSHVF AAVNVTNTSD VVDDIRKCGY LRKQKHGHKR FFVLRAASQL
GPSRLEYYDS EKKFRNSLRS AAAAAAAASG GAVAPSPPKR VIYLYQCFTV NKRADSKNKH
LIALYTKDEY FAIVAENEQE QEDWYVAVSE LMSEGKKGHL DSDDLDDGYG TVTPGTVFKE
VWQVNVKPKG LGQTKNLTGV YRLCLSSKTI HLVKLNSETP CVNLQLMNIR RCGHSESFFF
IEVGRSSSIG PGEIWMQVDD SVVAQNMHET ILEMMKALKA FAEFRPRSKS QSSGSNPMSF
ITTRRHLGNL PPSQTGLQRR SRTESVVGTP PSSKSSGASG YRFRTSSEGE GTMNRPFRST
TGSLLHLNAA RAHHGRQEAD GGSSGSGVAT GNAGTSTGGG RYVRAIPGSS TYHARSASLP
VSHFPSTTSP VSVSSSSGHG SVSDTLTRPS SASICGSPSD GGFNSSDEYG SSPGDFRYFR
VRSNTPDSLG NTPPIREENC LNDYMAMGWN REVFGTSVCS GNSSGCDTPR EESLVAAEDE
RFSSSSLRRR THSFSRPAGG ATGGSGVAVY QKMTQTNFSL DEGSDVALPF GSGLLRGGPS
SSSSSLRSDY SSCSEHSQQS RPCALSRLDP GGERAPISSA KEDSGYMPMM CGVAASPRET
APDYMPMQPS SYSHPISHSP QFHSPALGTQ SAQRPQSQSQ SSTDSHGYMM MLPGGSGSSP
SPRQGSPGPP SGSSVPSDSV GERPENGEYM DMSYSSSGGR KLSNEASGSY YMPGTPEGTS
KSYSPYFSLP RSYKAPTRQR DEKEYGEYVP MSSPAKPVYA SVATASATTP EKRSGGGGGG
TSTPSHPPPP YGAHHATAAM ADRRVVRPNR LPLGRRSFHG PLRVSEPSTA SANINTSVPV
SSSEEASSPG EYINIEFGEH YPQQQQPPAY HLSGTASTRS NDHRRSPPQP QTHQDYMSVE
VGANQDSAEC LERKQSPRPS LVAPWNPPSY IRPLASNPGA ISSPVVPPSG GHWRSMGDEY
TDMTFNLSRN DRAQTSPTAM LQHLCVMEGH YSHAAASSSS SISPTLPPTS PNRLPTHQTE
PKVVRADPQG RRRHSSETFS STSSSNSTPP GGGDPSSSVG HHTASNGSYV TEGQASKWAT
SASFDNMWMS MEGLGDAAAP HTAVRSSEIS TNSEISASTS SLAGAGRTCR NSSVGYQNGL
NYIALELRED GSNAAPAASG AGSSNGSSAA GAAPPLENGT YASIDFTKSD VVTTTTKD
//
