ID A0A3B5K0J6_TAKRU Unreviewed; 199 AA.
AC A0A3B5K0J6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Dickkopf-related protein 3-like {ECO:0000313|Ensembl:ENSTRUP00000050981.2};
GN Name=LOC101074102 {ECO:0000313|Ensembl:ENSTRUP00000050981.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000050981.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000050981.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000050981.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the dickkopf family.
CC {ECO:0000256|ARBA:ARBA00010842}.
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DR AlphaFoldDB; A0A3B5K0J6; -.
DR Ensembl; ENSTRUT00000049497.2; ENSTRUP00000050981.2; ENSTRUG00000020464.2.
DR GeneTree; ENSGT00390000000221; -.
DR InParanoid; A0A3B5K0J6; -.
DR OMA; GPSMCCA; -.
DR OrthoDB; 3058712at2759; -.
DR Proteomes; UP000005226; Chromosome 1.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR Gene3D; 2.10.80.10; Lipase, subunit A; 1.
DR InterPro; IPR006796; Dickkopf_N.
DR InterPro; IPR039863; DKK1-4.
DR PANTHER; PTHR12113:SF31; DICKKOPF-RELATED PROTEIN 3-LIKE; 1.
DR PANTHER; PTHR12113; DICKKOPF3-LIKE 3; 1.
DR Pfam; PF04706; Dickkopf_N; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..199
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025653077"
FT DOMAIN 57..103
FT /note="Dickkopf N-terminal cysteine-rich"
FT /evidence="ECO:0000259|Pfam:PF04706"
SQ SEQUENCE 199 AA; 22424 MW; A7CBE924E4DB45BE CRC64;
MSEMSGKPSL LFLCFCVSVA EAHIWAWMLN MPHRPPKDGV RSPREHPPVA RAATAVCDQE
RACGRGFSCD RHFGVCVPQR GEGHYCRRDA QCVRGLRCMF GKCHRSIPSG QEGARCKVDR
DCLSSMCCAR HHGERVCKRR LVRGAGCYIP DGGLAFSINQ ICPCDEGLLC REDSAPHRRE
RDFIYQPEWK TWTCQAPTP
//
