ID A0A3B5K1D5_TAKRU Unreviewed; 803 AA.
AC A0A3B5K1D5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Methyl-CpG-binding domain protein 1 {ECO:0000313|Ensembl:ENSTRUP00000049262.2};
GN Name=LOC105417876 {ECO:0000313|Ensembl:ENSTRUP00000049262.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000049262.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000049262.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000049262.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B5K1D5; -.
DR STRING; 31033.ENSTRUP00000049262; -.
DR Ensembl; ENSTRUT00000049096.2; ENSTRUP00000049262.2; ENSTRUG00000013422.3.
DR GeneTree; ENSGT00950000183005; -.
DR InParanoid; A0A3B5K1D5; -.
DR OMA; CQGMPPK; -.
DR Proteomes; UP000005226; Chromosome 19.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR002857; Znf_CXXC.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF02008; zf-CXXC; 2.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS51058; ZF_CXXC; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00509}.
FT DOMAIN 133..201
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 335..381
FT /note="CXXC-type"
FT /evidence="ECO:0000259|PROSITE:PS51058"
FT DOMAIN 453..500
FT /note="CXXC-type"
FT /evidence="ECO:0000259|PROSITE:PS51058"
FT REGION 1..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..32
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 803 AA; 90738 MW; 332259C143D15E0B CRC64;
MSQEPESPVP SKEPEENLGE ITDEDNTEDG STSEEAAQDP MEPSQPKTER PNSVAVREIL
GEEMEDSKAA FDEAPVDWFE PVEEDEEFDG IGKKDPEEES VAGESERSES VYGSEKAYKK
VFHRVPRRRR SHPDEGWVEW PVLGEGWKRK EVVRRSGCSM GQKDVYYMGP HGDRFRSRVE
LVSVLNGILD LTTFDYKTGQ FWDGKIPPIR SRTRKRKARE RSSSESSWME RDEGADTPDS
LHTLTPSLGA KNHCNQDSSH RYPPAEDKIK LPLFSQSSRR MPVPSINGEI GSEDKTLVCA
KCGVSFTGTW YDKQRKRPCC PMCWAASKHK EHPMIRFRKW IPCGQCVGCH NTVNCGQCAN
CKHGTQSPES RRRLCRKRKC ICPVRKGSGS GSFLQQMSYD SPDPITDGVR LKAEVTDPQY
PSFKSSDTEN LSLSLDMDDE DDVSTDDDED WHKKRKRRSC GECKACLCRK DCGTCDFCID
KPKFGGSNKK RQKCRLRQCQ RQAMRHLLPF QMGQDDCEQD GAAPPGRPRP HYTYSRKSTF
KKNKGAASGL DLTDNEDDNS NSKVISWSTE PAGPPTETDV RSKQASKELV NDLDSGQKNG
LPEKDVKVNH LDSELEHLSR WDAEKSHPVR DSPKHPDEDE KEEFPKITET FSLADVPAGS
AADAESQLMK LLQSLRTTVL PILWYAIMVQ GPQLQLIQCS KRSTMTDTIV IIDPGFYYKI
TVQKQPLLPT HPLYDQHPGR LTSAGEVVNL LLALEKYVVC HGLPPKQNFY YKDPLILERA
STCHFLVKKK EGVCSNCQAL RGF
//
