ID A0A3B5K292_TAKRU Unreviewed; 1197 AA.
AC A0A3B5K292;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Contactin associated protein like 3 {ECO:0000313|Ensembl:ENSTRUP00000050068.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000050068.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000050068.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000050068.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3B5K292; -.
DR Ensembl; ENSTRUT00000058213.2; ENSTRUP00000050068.2; ENSTRUG00000001496.3.
DR GeneTree; ENSGT00940000160228; -.
DR Proteomes; UP000005226; Chromosome 22.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0032101; P:regulation of response to external stimulus; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.1000; -; 1.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR15036:SF40; CONTACTIN-ASSOCIATED PROTEIN-LIKE 4; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00122}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1132..1154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..92
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 97..282
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 288..472
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 463..500
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 499..551
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT DOMAIN 710..875
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 876..914
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 932..1101
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1163..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 848..875
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 1197 AA; 130909 MW; A95A3ADB311BAAA2 CRC64;
GERTKVTAVA TQGRYGSSDW LTSYLLMFSD TGHNWKQYRQ EDSLGSFPGN SNADSVVQYK
LQQPVVARFL RLIPLGWNPN GRIGLRLEAY GCPYTSDVAS LDGGSSLTYS PSPALKRTFR
DVVTLKFKTV RNSGMLLHAG GAGGLGLSLE LERGKLQLLL RQGKEKPPGQ ASSAEPRRLA
SLGSLLDDQH WHRVAVERRG VHLNVTVDKH TEKVRVPAEF GHWDVQQLNV GGGPGLGPET
PGRSGRNFHG CLENLLYNGH SLIDLVKQKS RQVAVGNVTF SCDEPLSVAV TFPGPQSFLQ
LPGVPASSSG SFSVGFQFRT WNGAGLLLTF ALPQEGGVVW LYLSEARLRL QIHKAGRVLL
ELSAGWALND GQWHQAELKS RRGRLSIVVD KEERSSAHAS HSLPVAIESS IFFGGCPTEG
DVQGCRNPFH VFQGCMSLLT LDDQKVNLIL VQQKQLGTYG NLQLDIGAQS PCEHGGRCTQ
SWTGFHCNCS DSGYSGATCH SSAYERSCEA YKHAGSTSGH FYIDVDGSGP IGPQLVYCNM
TEGNTWMEVP HNNTELTRVG AAPDANQRSV YFDYAAGEEQ LAAAIGQSEH CQQELSYHCR
KSRLLNTPEG SPFSWWVGGP GPGRVQTYWG GAQPGSQQCA CGLQGDCVDP QHYCNCDADR
AEWAQDSGPL AHKESLPVRS LLLGDIQRPG SEAAYRVGPL RCHGDRNFWN AAFFDRETSY
LHFPTFHGEL SADISFLFKT TASSGVFLEN LGIKDFIRIE LSSSSQVLFS FDVGNGPLEV
RVDSSVPLND NRWHRVRAER NIKEASLQLD DLPAAMQEAP AEGHFHLQLN SQLFIGGTAS
RQKGFRGCIR SLQLNGVTLD LEERASITPG VQPGCPGHCS SYGSFCQNHG RCVERVNGFH
CDCGLSAHAG VFCHTEVSAS FKPATSVSYT FKEPYEQVRN SSAVPSSIYT DVTLRGENVT
LSFRTFQSPA VLFYVSSYHR EFLAVLINKH DKLEVRYKLD SSRDAEVMRS RVRHLANGRL
HSVSIRRLSE SMLRLPHLAV VLCPSSGSDD LDPDLLRLGS LGFAGCLSVV RFNSISPLKA
ALLHPDTSPV TITGPLLRSG CGSASANPSA TEDTHLLTGR RRELNLDLLC PAGVIAVAIF
LMVAGLAIAG RFLYRRKETY RNQEVKGVKQ EDGPDFPFSS QAESQDASEE NPKEYFI
//
