ID   A0A3B5K4H6_TAKRU        Unreviewed;       852 AA.
AC   A0A3B5K4H6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=HECT domain E3 ubiquitin protein ligase 3 {ECO:0000313|Ensembl:ENSTRUP00000052523.2};
GN   Name=hectd3 {ECO:0000313|Ensembl:ENSTRUP00000052523.2};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000052523.2, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000052523.2, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000052523.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B5K4H6; -.
DR   Ensembl; ENSTRUT00000053265.2; ENSTRUP00000052523.2; ENSTRUG00000007419.3.
DR   GeneTree; ENSGT00940000159923; -.
DR   InParanoid; A0A3B5K4H6; -.
DR   Proteomes; UP000005226; Chromosome 22.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd08666; APC10-HECTD3; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR004939; APC_su10/DOC_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR042469; HECTD3.
DR   PANTHER; PTHR46654; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR   PANTHER; PTHR46654:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR   Pfam; PF03256; ANAPC10; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM01337; APC10; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS51284; DOC; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          209..387
FT                   /note="DOC"
FT                   /evidence="ECO:0000259|PROSITE:PS51284"
FT   DOMAIN          522..848
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   ACT_SITE        814
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   852 AA;  97049 MW;  CC3A72EEEB9FD3A4 CRC64;
     MCNNPHLLLG RIRFLNRCIE CLKRSESMPE SLCYIPKEVC YKVCKDSSFT TSASSGVPAG
     GAKTLIPVFD IPLQTPHIKK LCKYNIELKK GTCIRTTGEQ YRNSQGLWVK ITKEQMEEHR
     PGIELEEGWI LVCKNTEGGD KLVPVESPET ITRQQQLFGY DHKPCNVWEE VVNVENALYI
     GSKPKIAESD DAAVQKLRYI PPTWTYECDE DLVHYFYDHI GKEDENLGSV KQCVTSIDVS
     SSSVSGGVSC LTDGDNETYW ESDGMQGQHW IRLHMKRGTI VNKLMLMVDS TDDNYMPKRV
     TVFGGEGDGL KKLSDVTLDD NLIGEICVLE DMTSHLPIIE IRIEECRDEG IDVRIRGLKI
     KSSCERDLGL NADVFQSSNL VRFPRLQGNS PDMLYRRTLV IQRLFITLLD SVLPHLVPAW
     DYSLDTFNQI KTIKQFLLLS KRRSALITQC LKDSETSKPD FMPRLYINRR LAMEHRDNPS
     LDPSCKNAVF SQVFEGLKPS DKFEKTLDYR WPARYDQWWE CKFIAEGIID QGGGFRDSLA
     DMSEELCPSS AECAMPLPFF CRTSNQGAFE ARDYYVPNPS CKEFHKFEWI GQLMGAALRG
     KDFLVLALPG LVWKQLTGEA VHWNKDFPAV DSVLVNFLEA MEHMDKETFE FRFGEDLVYT
     TLLSDGQMVE LIPGGSNISV CYEDRSKFIH LVQKARLEES KQQITAMQAG LLKVVPQAVL
     DLLTWQEAEK KVCGDPEISV DALKRLTHYE DLEPSNIRVQ YLWEALTNFT NEDRSRFLRF
     ITGRSRLPAP IYIFPDKQGS VSETTDALPQ SSTCSSTLYL PNYPSAKVCE EKLRYAAYNC
     VAIDTDMSPW EE
//