ID A0A3B5K7Y7_TAKRU Unreviewed; 424 AA.
AC A0A3B5K7Y7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Class E basic helix-loop-helix protein 40 {ECO:0000256|ARBA:ARBA00040229};
DE AltName: Full=Class B basic helix-loop-helix protein 2 {ECO:0000256|ARBA:ARBA00042387};
GN Name=BHLHE40 {ECO:0000313|Ensembl:ENSTRUP00000049475.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000049475.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000049475.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000049475.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_003973151.1; XM_003973102.2.
DR AlphaFoldDB; A0A3B5K7Y7; -.
DR STRING; 31033.ENSTRUP00000049475; -.
DR Ensembl; ENSTRUT00000057941.2; ENSTRUP00000049475.1; ENSTRUG00000024300.2.
DR GeneID; 101063749; -.
DR KEGG; tru:101063749; -.
DR GeneTree; ENSGT00940000158384; -.
DR InParanoid; A0A3B5K7Y7; -.
DR OMA; AMSQTPM; -.
DR OrthoDB; 2968390at2759; -.
DR Proteomes; UP000005226; Chromosome 19.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19749; bHLH-O_DEC1; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF3; CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 40; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 47..102
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 135..168
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 181..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 424 AA; 47018 MW; 72E98D5E0636FAF4 CRC64;
MERIPSAQPP PLSKHQADLS DVQGMDFPMY VYKPRRGLKR GEENKETYKL PHRLIEKKRR
DRINECIAQL KDLLPEHLKL TTLGHLEKAV VLELTLKHVK ALTSLLEQQQ QKILALQNGV
QIEQPPVNQE KSEMFRSGFH MCAKEIHQYL VNHEADGDFT PSHVINHIQK VAAEVLQSPV
RPCTPVSPRA EEAPAYRQHG PHKEMPANTP AKPGEGYGRN CVPVIQRAYA PTSSEQSGSD
TDTDSGYGGE LEKTESGAPQ GRPVYYGQES QPKRSLSERQ SSAIKQEDEE PRHKRPRAES
LEDELLSSGE SLSPPRGYGS YSVSPNHPPP SHPLCMPFYL IPPSAAAYLP MLEKSWYPGT
VPILYPGMGG SSSAMPKERP SPPQLMLSPR GGSPAPAMSQ TPMDSPTLLQ ALKQVPPLNL
ETKD
//
