ID A0A3B5K802_TAKRU Unreviewed; 564 AA.
AC A0A3B5K802;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=BTB domain-containing protein {ECO:0000259|SMART:SM00225};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000053788.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000053788.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000053788.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3B5K802; -.
DR Ensembl; ENSTRUT00000005810.3; ENSTRUP00000053788.2; ENSTRUG00000002493.3.
DR GeneTree; ENSGT00940000164299; -.
DR InParanoid; A0A3B5K802; -.
DR OMA; ENQECCE; -.
DR Proteomes; UP000005226; Chromosome 18.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003972; K_chnl_volt-dep_Kv1.
DR InterPro; IPR004050; K_chnl_volt-dep_Kv1.3.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF104; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 6; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01510; KV13CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR PRINTS; PR01496; SHAKERCHANEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..136
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 413..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 63906 MW; E5444B6CEAC111A9 CRC64;
MTVVSGENLE ETVALAALSA QDVGVPERED SQECCERVVI NISGLRFETQ LKTLARFPAT
LLGDPRKRMR FFDPLRNEYF FDRNRPSFDA ILYYYQSGGR LRRPANVPVD IFLEEIKFYE
LDEEVIDNFR EDEGFLKEEE RPLPQNEFQR QVWLLFEYPE SSLPARGIAI MSVLVILISI
VIFCMETLPE FRKEARAFDA LLSANNTASA NKPNPFTDPF FIVETLCIVW FSFELLVRFL
ACPSKAAFFK NILNTIDIVA IIPYFITLGL ELAEHQGGGE QATSLAILRV IRLVRVFRIF
KLSRHSKGLQ ILGQTLKASM RELGLLIFFL FIGVILFSSA VYFAEADEPE SHFSSIPDAL
LVGRGYHDNR GLRRHATGDS RGERSWAPLC AIRRRADHRA SRSGHRVQLQ LLLHTPRDGP
GPVVPEGRAQ RRPGQSRAEA QGQQSVHGIS GRGERREVRG EGRHQSQQQR GLQEVPVRLL
SGHARDGPVT PPLFIKARSG VEEPPTSAGE TFDLLYRRHQ APRIMGKWNI ISQGAGIKTW
LGLKTNLYFH TRPDAVDMFT LTFS
//
