ID A0A3B5K9A5_TAKRU Unreviewed; 995 AA.
AC A0A3B5K9A5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Insulin receptor substrate 2-like {ECO:0000313|Ensembl:ENSTRUP00000054268.2};
GN Name=LOC101076043 {ECO:0000313|Ensembl:ENSTRUP00000054268.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000054268.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000054268.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000054268.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B5K9A5; -.
DR Ensembl; ENSTRUT00000054859.2; ENSTRUP00000054268.2; ENSTRUG00000009972.3.
DR GeneTree; ENSGT00940000161407; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01257; PH_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF7; INSULIN RECEPTOR SUBSTRATE 2; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 18..119
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 196..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 995 AA; 107539 MW; 0811B3BC4E255D41 CRC64;
MASPPTTAGH LLSNETSGVK KCGYLRKQKH GHRRFFVLRE PTERCPARLE YYESEKKWRN
KSAPKRVITL DSCLCVNKRA DAKHKHLIAL YTKDEYFAVA ADNEGEQESW YAVLTELIAE
GKVYDSPMST SSLVGFEEAS YGLITPATSA YKEVWQVGRS AVTGPGEFWM QAEDPVVAQN
IHETILGAMK AMKELSEFRP RSKSQSASTN PISVPTRRNL SNLPPSQTGL VRRSRTDSIA
ATSPGKKFTS CRIRTASEGD GSVTRPASMS ISVNGSPTSP NSGSHLSRSH TLISGRTCRM
IESSSNLHHS QSMPVSNSPP AASSPISMSP KGGTGTSTPD KVRRPFSCSA SISGSLSDAG
FILCEDYSSS PGDPRFLPLT RSDTPDSLSS TPPSRDIGDL CDYMLMEGTN SSRAGACGDC
LTFDKVYRKR THSLTTPRQQ RVVAPLSSAS LDEYTLMRMA HGQNSHSASP KVCYPEDYGD
IEIGSSRSSS SNLADDGYMP MTPGVASQSG KADNYVPMSP MCVSAPKQII NPRVHPQAAT
NGGFKTNSPC SSSLEDNGYM RMWCGSRSSM DSPDRHGEYM NMSPGNPPPL QTPPDYYPGL
LAGEAASVRA VYQAGSLALP AKVQATKPEE SSQYVLMSPQ SSRQKMGESD YYSVMQPVVA
QCSSIPSPIR HSRPETLSYR GRLGRPNRLS LDTLRTLPSM NEHPLPGEPR SPGEYINIDF
SSTRYSPPST ISSESQPSSL GSSSGGPGRS SLTEYINVEV SLNSLKQAPA ERLDTLPELS
QYPCPEDGVY HLDGEKRSQG LCDEAKNDYS EMKFGVTSSP PQLVPQNAAG KASMERRITL
EDQGIPEGIG VFLIGTASST VDPDCSAKVI RANPQGRRRH SSETFSSTTT VTQVFPSFAR
GDAMKRHSSV ENISSRSSEG SDDEYGSPVI RQSSAGYPNG LNYIALNLLE NRNGEKCEDI
TGFKPTSSCK GGINGLHSTP YVCLGFKEAA TTAKD
//
