ID A0A3B5KA01_TAKRU Unreviewed; 379 AA.
AC A0A3B5KA01;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=E74 like ETS transcription factor 3 {ECO:0000313|Ensembl:ENSTRUP00000050200.1};
GN Name=elf3 {ECO:0000313|Ensembl:ENSTRUP00000050200.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000050200.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000050200.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000050200.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR RefSeq; XP_003973106.1; XM_003973057.2.
DR AlphaFoldDB; A0A3B5KA01; -.
DR SMR; A0A3B5KA01; -.
DR STRING; 31033.ENSTRUP00000050200; -.
DR Ensembl; ENSTRUT00000054999.2; ENSTRUP00000050200.1; ENSTRUG00000024589.2.
DR GeneID; 101071910; -.
DR KEGG; tru:101071910; -.
DR CTD; 1999; -.
DR GeneTree; ENSGT00940000158955; -.
DR InParanoid; A0A3B5KA01; -.
DR OMA; ELNETCQ; -.
DR OrthoDB; 3686750at2759; -.
DR Proteomes; UP000005226; Chromosome 19.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd08537; SAM_PNT-ESE-1-like; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042693; Elf-3_PNT.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF13; ETS-RELATED TRANSCRIPTION FACTOR ELF-3; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 38..125
FT /note="PNT"
FT /evidence="ECO:0000259|PROSITE:PS51433"
FT DOMAIN 284..366
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 208..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 379 AA; 42599 MW; C9BE23C3C3B33A29 CRC64;
MSSLSLSSVL TGANFAMYQS TVSDVPQQPA SINTMNTNNT AYISNLSGQS YRQIEPQYWT
VDNVLEWISD HVESNKFDAH SLSLALCSMD GYSLCQMAQD QMIEAFGSQL GSHLYHSLQE
HKTNYAFADL QSFPGSELNE TCQILDNLLD NFPLLSTIII RPDEGEPGVR DPLCGNENDL
GGFALGSVMA QEDLEYLSDV QSDSDFSSSS NSGAFFQSPG SPDSVSGESD PEFCYPLISK
SFIKTEKAES RLKRPRGRPP KLSGEHSSTV YAGSKKSKHA PRGTHLWEFI RDILINPEKN
QGLMKWEDRH EGVFKFLKSE AVAQMWGQKK KNSTMTYEKL SRAMRYYYKR EILERVDGRR
LVYKFGKNSS GWKIEEIGM
//
