ID A0A3B5KDQ4_TAKRU Unreviewed; 525 AA.
AC A0A3B5KDQ4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
GN Name=LOC101072688 {ECO:0000313|Ensembl:ENSTRUP00000055816.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000055816.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000055816.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000055816.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Probable chloride channel. {ECO:0000256|RuleBase:RU361114}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361114};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU361114}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the tweety family.
CC {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
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DR AlphaFoldDB; A0A3B5KDQ4; -.
DR Ensembl; ENSTRUT00000049924.2; ENSTRUP00000055816.2; ENSTRUG00000009676.3.
DR GeneTree; ENSGT00950000183060; -.
DR Proteomes; UP000005226; Chromosome 5.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR006990; Tweety.
DR PANTHER; PTHR12424:SF17; PROTEIN TWEETY HOMOLOG 2-LIKE; 1.
DR PANTHER; PTHR12424; TWEETY-RELATED; 1.
DR Pfam; PF04906; Tweety; 2.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|RuleBase:RU361114};
KW Chloride channel {ECO:0000256|RuleBase:RU361114};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU361114};
KW Ion transport {ECO:0000256|RuleBase:RU361114};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361114};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361114};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT TRANSMEM 78..107
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 119..142
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 380..405
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
SQ SEQUENCE 525 AA; 58000 MW; 3A6B461621AE5F0D CRC64;
MAGGEHPLWS SSSAQRAPAA HGKCLVGELS PAGMAAARLD YVAPWWTYWL HNFPHFDFLF
QPVDNAFRPE EQSYQQSLIL LACVGAVGLG LSLLVLVVYL VCLCCCCRDI DEDTKKPEAC
CVTWVAVASG LILCSAVGVG FYGNSEANDG VYQLTYSLHN ANQTLGGINN LVAGSAGNVE
TGLKQHLERL DEIFAARPDY LQTLRFVQLM VNNVVRELTA LPDISKANVD VASIADQTAL
AEYYRWLTYL LLLILDLVIC LAMCLWMAKQ SRWLLITIMA FGALSLILSW ASLGAGAATA
VSLTVCQRSL TTMQIQVQGL LQFSTPFFPT ARRDLLGIQR LLNSTEFNVH QLTALLDCRG
LHKDYLDALM GVCYDGVEGL LYLSLFSLLA ACALSIMLCI IFRFWTLIGS RDKEYDDIDE
EDPFNPEARR ISYHSRRSNI QSFCSYTSSM SSQASLPTPP QTASNVLPPP EYMNQSMLFG
GNPQYENVPL IGRGSPPPLY TPTMRNTYLS MTDAQVRHFG TDFHV
//
