ID A0A3B5KF02_TAKRU Unreviewed; 144 AA.
AC A0A3B5KF02;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Solute carrier family 48 member 1 {ECO:0000313|Ensembl:ENSTRUP00000051988.1};
GN Name=slc48a1 {ECO:0000313|Ensembl:ENSTRUP00000051988.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000051988.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000051988.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000051988.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=heme b(in) = heme b(out); Xref=Rhea:RHEA:75443,
CC ChEBI:CHEBI:60344; Evidence={ECO:0000256|ARBA:ARBA00035075};
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004265}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the HRG family. {ECO:0000256|ARBA:ARBA00006203}.
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DR RefSeq; XP_003963508.1; XM_003963459.2.
DR AlphaFoldDB; A0A3B5KF02; -.
DR Ensembl; ENSTRUT00000050220.2; ENSTRUP00000051988.1; ENSTRUG00000019716.2.
DR GeneID; 101074998; -.
DR KEGG; tru:101074998; -.
DR CTD; 436697; -.
DR GeneTree; ENSGT00390000002307; -.
DR InParanoid; A0A3B5KF02; -.
DR OMA; YLSCIWS; -.
DR OrthoDB; 2914891at2759; -.
DR Proteomes; UP000005226; Chromosome 3.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:Ensembl.
DR InterPro; IPR026218; HRG.
DR PANTHER; PTHR31525; HEME TRANSPORTER HRG1; 1.
DR PANTHER; PTHR31525:SF1; HEME TRANSPORTER HRG1; 1.
DR Pfam; PF16954; HRG; 2.
DR PRINTS; PR02095; TRNSPORTRHRG.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 35..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 144 AA; 16383 MW; 7B63B71E9017DFEA CRC64;
MGVSRIYISI GYATFGTLVG LSAFLVWNIA YKQPWTAAMG GLSGVLALWA LVTHIMYVQD
YWRTWLKGLK FFIAIGVFFS ALAVAAFIIF LTLAITEKQT PTDPRSLYLS CVWSFLSLKW
SFLLALYSYR YRQEFADISI LSDF
//
