ID   A0A3B5KLQ4_TAKRU        Unreviewed;       575 AA.
AC   A0A3B5KLQ4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=RAD50 double strand break repair protein {ECO:0000313|Ensembl:ENSTRUP00000054319.2};
GN   Name=RAD50 {ECO:0000313|Ensembl:ENSTRUP00000054319.2};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000054319.2, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000054319.2, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000054319.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC       {ECO:0000256|ARBA:ARBA00004574}.
CC   -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC       {ECO:0000256|ARBA:ARBA00009439}.
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DR   AlphaFoldDB; A0A3B5KLQ4; -.
DR   Ensembl; ENSTRUT00000055935.2; ENSTRUP00000054319.2; ENSTRUG00000003700.3.
DR   GeneTree; ENSGT00390000018781; -.
DR   Proteomes; UP000005226; Chromosome 15.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR   GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038729; Rad50/SbcC_AAA.
DR   InterPro; IPR004584; Rad50_eukaryotes.
DR   NCBIfam; TIGR00606; rad50; 1.
DR   PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR   PANTHER; PTHR18867; RAD50; 1.
DR   Pfam; PF13476; AAA_23; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Chromosome {ECO:0000256|ARBA:ARBA00022895};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Telomere {ECO:0000256|ARBA:ARBA00022895};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          6..233
FT                   /note="Rad50/SbcC-type AAA"
FT                   /evidence="ECO:0000259|Pfam:PF13476"
FT   REGION          420..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          203..233
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          265..349
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   575 AA;  66391 MW;  75044CC1F0B137B6 CRC64;
     MSRIDKMSIL GVRSFGIEDK DIQVISFFSP LTVLVGPNGA GKTTIIECLR YATSGELPPG
     SKGGAFVHDP KDAHETDVRA QIRLLFSDVN GEKVTIQRSM SCTQKAKNYS FKSLEQVITR
     IKDGEKVSLS SKCGDMDREM ISSLGVSKPV LNHVIFCHQE ESNWPLSEGK ALKEKFDAIF
     AATKYIKALE TMRQLRHKQT QTVKECQVEL RYLKQNKEKA QQIRETVATK EAQLMASRDS
     VQQIEDRITP LENQLTDIDT KLGKVMKLDN DIKALESRKK QMEQDNKELE ETMEQVFQGS
     DEQLQDVYQN HQRTVKQKER RLADNQKELE KAGRECQRLN RVKADLLVEQ GRLRLEADRH
     MDNIMTRDTQ VRSLSSYLGL EGYDRPPFSD LQLDSFHRHV TERLEQEKET VSQVMAELQE
     KEQRKQQSID DMRDKKTGLE RTVELKRDLQ GKKQQELRDI RAQLQRLEGS SSRLQELESE
     LAKVERELHS TIQSSNVEEL KNEVGELQRE KTDLDHSQRR LDKEMEMLNT HTTARTQMDM
     LNREKVSKQR GEFPEKELTS GFNLDNFELP LPGIL
//