ID A0A3B5KP87_TAKRU Unreviewed; 493 AA.
AC A0A3B5KP87;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=THUMP domain containing 3 {ECO:0000313|Ensembl:ENSTRUP00000055190.2};
GN Name=thumpd3 {ECO:0000313|Ensembl:ENSTRUP00000055190.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000055190.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000055190.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000055190.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000256|ARBA:ARBA00008361}.
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DR AlphaFoldDB; A0A3B5KP87; -.
DR STRING; 31033.ENSTRUP00000055190; -.
DR Ensembl; ENSTRUT00000056076.2; ENSTRUP00000055190.2; ENSTRUG00000004420.3.
DR GeneTree; ENSGT00530000063557; -.
DR InParanoid; A0A3B5KP87; -.
DR Proteomes; UP000005226; Chromosome 19.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd11715; THUMP_AdoMetMT; 1.
DR Gene3D; 3.30.2130.30; -; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14911:SF13; TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE THUMP3; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SMART; SM00981; THUMP; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF143437; THUMP domain-like; 1.
DR PROSITE; PS51165; THUMP; 1.
DR PROSITE; PS01261; UPF0020; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 163..267
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
FT REGION 473..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 54911 MW; 4AD111C6763E85B6 CRC64;
MATYDIDRLI VGLSLDVICE SEVCRQVSTH TSNDANAAHI ITVTVGATVP TGFEHTAAEE
VKEKIGVDVH ISKDRGRIYF PITTDKLFQV HLLRSVDNLF VVVDRYDHYT FKESKEETLK
ELQELASKLP WTNALEVWKL NRSFKKKKCF RKGGSGAKTK PNTEAVDATT EEQDLPQAAA
AVETQANVEG IPEEEESTEA APEAKVIKFR VTCSRAGDKH SFSSNEAARD FGGAVQEFFQ
WKADMTKFDV EVLLNIHNDE VVIGIALTEE SLHRRNISHF GPTTLRSTLC YGMLRLCKPQ
ASDIILDPMC GTGAIPLEGA IEFNSSFYVA GDNNDMAVNR TVNNVFHIQR RRADKGSASG
MPIDTVRWDL CSLPIRTSSI DIIITDMPFG KRMGSRKKNW DLYPSCLREM ARVCRPGSGK
AVLLTQDKKC FSKALSRMGG LWRKLHTVWV NVGGLHAGVF LLKRTANTFG QTPEDVYESR
GADNAQEEEK ELS
//
