ID   A0A3B5KTY5_TAKRU        Unreviewed;       592 AA.
AC   A0A3B5KTY5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=heparosan-N-sulfate-glucuronate 5-epimerase {ECO:0000256|ARBA:ARBA00012087};
DE            EC=5.1.3.17 {ECO:0000256|ARBA:ARBA00012087};
GN   Name=glce {ECO:0000313|Ensembl:ENSTRUP00000056742.1};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000056742.1, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000056742.1, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000056742.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[heparosan-N-sulfate](n) = [heparan-N-sulfate](n);
CC         Xref=Rhea:RHEA:20197, Rhea:RHEA-COMP:9556, Rhea:RHEA-COMP:9557,
CC         ChEBI:CHEBI:58041, ChEBI:CHEBI:58287; EC=5.1.3.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00000434};
CC   -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004841}.
CC   -!- SIMILARITY: Belongs to the D-glucuronyl C5-epimerase family.
CC       {ECO:0000256|ARBA:ARBA00005584}.
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DR   RefSeq; XP_003969684.1; XM_003969635.2.
DR   RefSeq; XP_011608275.1; XM_011609973.1.
DR   AlphaFoldDB; A0A3B5KTY5; -.
DR   STRING; 31033.ENSTRUP00000056742; -.
DR   Ensembl; ENSTRUT00000053392.2; ENSTRUP00000056742.1; ENSTRUG00000024535.2.
DR   GeneID; 101074194; -.
DR   KEGG; tru:101074194; -.
DR   CTD; 100007670; -.
DR   GeneTree; ENSGT00390000006043; -.
DR   InParanoid; A0A3B5KTY5; -.
DR   OMA; RGVFMYF; -.
DR   OrthoDB; 5392022at2759; -.
DR   UniPathway; UPA00862; -.
DR   Proteomes; UP000005226; Chromosome 13.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0047464; F:heparosan-N-sulfate-glucuronate 5-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:InterPro.
DR   GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR010598; C5-epim_C.
DR   InterPro; IPR039721; C5-epimerase.
DR   PANTHER; PTHR13174; D-GLUCURONYL C5-EPIMERASE; 1.
DR   PANTHER; PTHR13174:SF3; D-GLUCURONYL C5-EPIMERASE; 1.
DR   Pfam; PF06662; C5-epim_C; 1.
DR   Pfam; PF21174; Glce_b_sandwich; 1.
DR   SUPFAM; SSF81853; Family 10 polysaccharide lyase; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          391..581
FT                   /note="D-glucuronyl C5-epimerase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06662"
SQ   SEQUENCE   592 AA;  66495 MW;  41AFE40D4E71D92E CRC64;
     MRCLAARVNY KTLIIICALF TLITVLLWNR CSSDTSLRFL PHAALVAPSA RVGDSSISSQ
     QHPPQPPEPP PVVGGSKFEE IDCLINDEAS IKCRRAGGEI YMPFGWMEKY FEVYGKVAQY
     DGYDRFEFQH SYSKVYTQRE PYHPDGVFMS FEGYNVEVRD RVKCISGVEG VPLSTQWGPQ
     GYFYAIQIAQ YGLSHYSKNL TERPPHVEIY DTAEERDSRA ITHPWSVPKG CSLSRVHDKS
     RATSVRQFNA QESSEGVSLQ LGNSKDFILS LDIKFTSNGS VSVVLETTEK GPPFTIHYVT
     STQLIAFKDR EITYGIGSRT TWSTLTRDLL TDLRKGVGLS NTKAVKATKI MPRRVVRLVL
     NGRGFVDNVT ISTTAHMAAF FAASDWLLRN QDDRGGWPIM VTRKLGEGFR ALEPGWYSAM
     AQGQAMSTLV RAYLLTKDQA YLNAALKAVG PYKVPSAQHG VKAVFMNKHD WYEEYPTTPS
     SFVLNGFIYS LLGLFDLTET AGEKLGREAR QLFSRGMDSL KAMLPLFDTG SGSIYDLRHF
     MLGTAPNLAR WDYHTTHINQ LQLLASIDSS PIFKDVVKRW KAYLKGVRAK HN
//