ID A0A3B5PT29_XIPMA Unreviewed; 1022 AA.
AC A0A3B5PT29;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Spectrin repeat containing nuclear envelope family member 3 {ECO:0000313|Ensembl:ENSXMAP00000021174.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000021174.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000021174.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000021174.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
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DR AlphaFoldDB; A0A3B5PT29; -.
DR STRING; 8083.ENSXMAP00000021174; -.
DR Ensembl; ENSXMAT00000022492.1; ENSXMAP00000021174.1; ENSXMAG00000024025.1.
DR GeneTree; ENSGT00440000039367; -.
DR InParanoid; A0A3B5PT29; -.
DR OMA; ACCLEDQ; -.
DR OrthoDB; 4106312at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0045111; C:intermediate filament cytoskeleton; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR Gene3D; 1.20.58.60; -; 3.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR47535; MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G; 1.
DR PANTHER; PTHR47535:SF2; NESPRIN-3; 1.
DR Pfam; PF10541; KASH; 1.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 4.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS51049; KASH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TOPO_DOM 1..972
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TRANSMEM 973..993
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 994..1022
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 964..1022
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 349..376
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1022 AA; 117361 MW; F867944A161246E7 CRC64;
MQTSDSQHEG SGPAMTQQEQ QEFTARLQEA DAWMKGIEEQ LKANDNTAGS RDALEARLRE
TEKIHSSAHN GRMIVDQALM AAEKLLQSGD EELRNSTNIK LKELKDQWDE TTTYITHCHS
RIEWVWLHWS EYLKAYEEFE LWLAKQRRSL DLDVELQMGL KEKLWQVEQQ MVIVSDIKSQ
AVLLERLLDE AAALHSRTED PSVDAKAQQR LQEDYVEVRD RAQERLMLLQ KFSEEHRMFH
SHVQKFQSWL VSKTKELTEL MKLEETPENK LRALKTVDEN VDCEEKTLQH IEGMADAVRA
NTSPAGAEAV QEEAEELRLG WQRLRQGLCE AEEGLRCSLD SHSQYATRCQ RLGDEIGRIR
EMLQELDQEL VDTQESKSCK EMTEEQMEGR WRKYSGVRNT LAGKETQVDL LKSQLKDLFR
FSEDPRHLTD GVLAVVKEHQ SVKSRASRLC SESELELRSL LQDPLLSFSQ WANSVSQVME
ASNNVNDFSN TAMLLQKIQG LLQKSTELQE RLSLLQVKGD LLDSVFGTES SDDLQGELSA
AVRTRELLHN QLLERKNRLE SLISRTKDFD EAYKQILATL SAFRERLLAA DVLQPDILAK
KSQLEQMLVL QKELEDGEAQ LTVLDTLVSS NQSSRTQYEK LCADWSELHR RVTVKVQDCD
DIVSDHECFH GDLLNMEKWI MVMRQKLDSF CSPTGGWSVE GRRPEAQKLL GEFPEKELHL
QQIEAQGGKV LRRTSTDGRV HIQKDLERLR QRWNDLLTLS LNLNRLQGGS TEIHSGSAAS
FGRFKSEPDH IMQVVDLSGT CQTDGPRRRL TAGREGSEAT ASSSGEDDSR GSRDLNQINW
REFEAWLSRE NEVLMKITRT DKSSLSAEEI RTRRGTLQAL ISRLPEGQQM FQLLLQQTQS
SQGEDETLEN LRYRWTLYKS KLKEVENNLI MTKPGLEERK ELELRRGAEN VKGTVSETRT
EKKRGLLYRI CRLALLLWLL FLALLLLAFL LPLMDDGNSC SLSNNFARSF NVMLRYDGPP
PT
//
