ID A0A3B5PT41_XIPMA Unreviewed; 543 AA.
AC A0A3B5PT41;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Perforin-1-like {ECO:0000313|Ensembl:ENSXMAP00000021712.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000021712.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000021712.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000021712.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
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DR AlphaFoldDB; A0A3B5PT41; -.
DR Ensembl; ENSXMAT00000041251.1; ENSXMAP00000021712.1; ENSXMAG00000030075.1.
DR GeneTree; ENSGT00530000063725; -.
DR InParanoid; A0A3B5PT41; -.
DR OMA; DVYVELW; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR PANTHER; PTHR46096; PERFORIN-1; 1.
DR PANTHER; PTHR46096:SF1; ZGC:163021 PROTEIN; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..543
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017224713"
FT DOMAIN 28..369
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 369..489
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 543 AA; 60476 MW; 99AD5D5134B8C30A CRC64;
MLPDSTSALL LLSVLLVHSS VLSCLIGTQS ECDVARFVPG HKMVGEGFDI VTLQRKRAHV
IDVKTYLSPN GSCTLCSNPL QNHAYQKLPS SVVDWSASSQ CSADIISSYH TSFSSLIKAY
TSQDTNDWTD GLKVQMFELV GTTAYKFAKQ QSKEDRYTLS THSVTCNHYK FVLSPTPPLS
AEFKRQLDIL PSHYDSSTMN EYRDLINTYG THYFRLVELG GRLRRLISSR SCLSTLNGLT
SSEIHSCLSM GVAVGLGKLK ISHVPKSCMG VLLNQDSATN FSSGLHQHHS EVLGGDGWLG
EFSIYKNDST AYMNWLKSLI EHPDVVSFSL RPLYQLVPNK LQQEGLKAAI EQYLNDTAVK
KLPQEPHCET TTPNLSSDCC PLHASRGNLS VTIVRGWKLY GDVIGKTDGY AKMFYGSKSH
KTQVIVSNDP QWNAEFDLGK VDTSLALKIE VWDQDLFYDD RLGRCEKYLI PGTHTFTCKA
TRGGIEVKYT LTCDPHLTGE KCSLYKPTPL VTGDCWKPFD GLCSGKFWIS LSEKRIFRAV
PRP
//