ID A0A3B5PT66_XIPMA Unreviewed; 618 AA.
AC A0A3B5PT66;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000020806.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000020806.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000020806.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
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DR AlphaFoldDB; A0A3B5PT66; -.
DR Ensembl; ENSXMAT00000041016.1; ENSXMAP00000020806.1; ENSXMAG00000018695.2.
DR GeneTree; ENSGT00940000156343; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR CDD; cd00176; SPEC; 2.
DR Gene3D; 1.20.58.60; -; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF434; ALPHA-ACTININ-1; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00435; Spectrin; 3.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00150; SPEC; 4.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 516..618
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 454..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 618 AA; 71294 MW; DDF286913EAE9C72 CRC64;
LLKAHLALEQ TVETYAETVG MLSQQCQHLL ELGHPESEQI TKQQSHIDRL YVSLKDMVEH
RKTKLEQQYW LYQLNKEVEE LEKWITEREA VASSTELGHD LEEVTVLQER FTKFASETNS
VGEQRMEQVN KMVNEMIDCG HSDAATIAEW KDGLNESWAD LLELMETRRQ MLAASQQLHK
FFTDCKEVLA QITGKMKQLP EVRASSFDWT AARLFTSLLY LRKVRQLQEN AAQLRTIYAG
EKAEAIMVKE QEVMDAWKEL LSSCEASRIQ VTSVTDKVQF FSVVRENLMW MEGIMGQIRW
DEPRDLTGLE VMMKHHQDLK AKVDGRSKTI QQCADLGKIL IAAGNPASEE IQEKLDSLLT
KQKDMIEKWD KHQERLLQQE HFQFAQETVK AEAWLKAKEP LMSSKQQEGE EAQAQTDEVE
QLILRHEAFR KAAVTWKERF SSLRQLSAVS FTARGEPYRP PSSLSAPVTR FDGRPRARDR
PKPRRRPRPK EPETTRRSRS APATGAPTTP QPPSHTAQNE GFLYRKKATS TDLEAHKSWV
NVYCVLKEGK LTFYKDTKNL TATYNGEPSV DMSDCKFDPS MGYKKKKNVF ILQVNDGTNF
VFHAKDEVRT LIHSYYIF
//
