ID A0A3B5PU47_XIPMA Unreviewed; 721 AA.
AC A0A3B5PU47;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Engulfment and cell motility 2 {ECO:0000313|Ensembl:ENSXMAP00000022440.1};
GN Name=ELMO2 {ECO:0000313|Ensembl:ENSXMAP00000022440.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000022440.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000022440.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000022440.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR AlphaFoldDB; A0A3B5PU47; -.
DR STRING; 8083.ENSXMAP00000022440; -.
DR Ensembl; ENSXMAT00000026593.1; ENSXMAP00000022440.1; ENSXMAG00000003634.2.
DR GeneTree; ENSGT00940000159236; -.
DR InParanoid; A0A3B5PU47; -.
DR OMA; XDMANAF; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR CDD; cd13359; PH_ELMO1_CED-12; 1.
DR Gene3D; 6.10.250.810; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR PANTHER; PTHR12771:SF8; ENGULFMENT AND CELL MOTILITY PROTEIN 2; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 317..486
FT /note="ELMO"
FT /evidence="ECO:0000259|PROSITE:PS51335"
SQ SEQUENCE 721 AA; 82674 MW; B3DCE612DCB6A186 CRC64;
MPPPADIVKV AIEWPGANAQ LIEMDQKRPL ASIIREVCDG WSLSGSEQFA LRYADGPQLY
ITEQSRGDIK NGTILRLAIS PARAARQLLE RIQSHGIDAR LEALKELAKL SADPTFAAEF
INMEGIGTLA RLVESGTHFG EMLAFTLTAF LELMDHGIVS WDMISLSFIK QIAGYVNQPM
VDVSILQRSL AILESMVLNS HSLYHRVAQE ITVGQLIGHL SNQEIQTYAI ALINALFLKA
PEDRRQEEYT NPLEQHLTEM ASTLAQKHLR SIILNHVIRG NRPIKAEMAH QLYVLQVLTF
NLLEERMMTK MDPNDQAQRD IIFELRRIAF DGDTDPTGTE KRKAMYTKDY KMLGFTNHLN
PAMDFTQTPP GMLALDNMLY LARVHQDTYI RIVLENSSRE DKHECPFGRC AIELTRMLCE
ILQVGELPNE GCNDYHPMFF THDRAWEEFF CVCIQLLNKT WKEMRATAED FNKVMQVVRE
QITRALAMKP SSIDQLKNKL RGLSYSEILR LRQSERMSQD DFQSPPIIEL RERIQPEILE
LIKQQRLNRL CEGSCFRKLG NRRRQEKFWF CRLSLNHKVL HYGDLEESPQ GEVPFELLSD
KIPVSDIKSV LTGKDCPHMK EKSALKQNKE VLELAFSVLY DPDETLNFVA PNKYEYCIWT
DGLCALLGRE MGSDLTRSDL DTLISMEMKL RLLDLENITI PEAPPPVPKE PSSYNFTYNY
S
//
