ID A0A3B5PW13_XIPMA Unreviewed; 839 AA.
AC A0A3B5PW13;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=DENN domain containing 1B {ECO:0000313|Ensembl:ENSXMAP00000021876.1};
GN Name=DENND1B {ECO:0000313|Ensembl:ENSXMAP00000021876.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000021876.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000021876.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000021876.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B5PW13; -.
DR Ensembl; ENSXMAT00000025286.1; ENSXMAP00000021876.1; ENSXMAG00000002440.2.
DR GeneTree; ENSGT00940000155446; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 6.10.140.1000; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR040032; DENND1A/B/C.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR13196; DENN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR13196:SF24; DENN DOMAIN-CONTAINING PROTEIN 1B; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 13..357
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 406..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..496
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..686
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..775
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 839 AA; 93359 MW; 4AF811555FF00890 CRC64;
MDSRIKENPE RTFDLVVQVA CPSSENEDPT VLWSFPQDHT DQEVLQTIPK FCFPFDVERV
SQNQVGQNFT FVLTDIDSKQ RFGFCRLTQG CRVCICLLSY LPWFEIYYKL LNTLADYLTK
QQENDLNDLL NSLYELPVPK PFTPVNLSVR NLTEYFVAVD INNMLQLYAS MLHERRIIIT
SRKLSTLTAC VHGAAALLFP MYWQHIFIPV LPPHLLDYCC APMPYFVGVH YSLLERVRSR
SLEDVVILNV DTNTLETPFD DLHNLPSDVV SILKGKLKKQ STATGSGVAG AFLRAQAALF
GSYRDALRYK PGEPITFCEE SFANHRSSTM KNFLSMAVNL QLFKQFIDGR LAKLNAGRGF
TDVFEEEITE GGFCGSNSRS YQQWMHTVKR GGAFFNTAVS KAKGHARRGI RDFKDRLKAK
EDEEDGMTVR PGSPTSTKSL SPRRLQKMRR HNLNKSPMSM GPRELGYGLD DDELDNASKI
SSEDSGEVRS YTEDSDDSDS FYPDIDPSPS SQMNLLEEIL DSLTTTTMDQ GKLSAAKSLD
FFRSLDDLDF KVQSKPSPCS DSTAADDSSF DGGADHGGWN MGQDDSAVHG KHLPPSPRRQ
PNKSSLKGSK NLAAFSAVTR CSASPPSNDA NGTKSDPPPL FSSKSRPDSH LLMPSGRPPG
DHRLSYSPLL PHKVTPPSPP APQPDSSPEL TSRSRTISDP QGNSEPSQTQ NQTGSTGILR
RKVMSKEMVK NYHERSIRRQ RGGNHESQAS PMKSSHVQVP WKKEEEERKE EKEAPKDKLL
GFGLCLGQCE GSETAGGPDP GLLEEIESMC CLSSSLHSSL HLSQVHCSNS HQGKATEKS
//
