ID A0A3B5PWG1_XIPMA Unreviewed; 1245 AA.
AC A0A3B5PWG1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Dynactin subunit 1 {ECO:0000256|ARBA:ARBA00016574};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000022344.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000022344.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000022344.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynactin 150 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00011010}.
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DR AlphaFoldDB; A0A3B5PWG1; -.
DR Ensembl; ENSXMAT00000026743.1; ENSXMAP00000022344.1; ENSXMAG00000008912.2.
DR GeneTree; ENSGT00940000155378; -.
DR OMA; HINQRIA; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR022157; Dynactin.
DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR PANTHER; PTHR18916:SF6; DYNACTIN SUBUNIT 1; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF12455; Dynactin; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 34..76
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 193..499
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 928..1019
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1152..1179
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 84..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1245 AA; 137721 MW; 5D7E4CFB924D4EDE CRC64;
MSSTGSVESV KPPKIGSKVE VTGKGQQGTV AYIGATLFAS GKWVGIILDE PKGKNDGTVQ
GKRYFSCEEN HGIFVRSSQI QVIDDGSAAT SPETPDASLA KTLKQKDIPE TPKTTKQTPA
NVKKSSTRRS AKASRESLLA SLPGDVSEVS LSSQQVALVA PVTPQPSSSP SSVAPQAPVT
PSKVEPAISK QEEDSLRALV KDLEEKLETL KIKRTEDKAK LKELEKYKIQ LEQLQEWKTK
IQEQQADLQK QLKEAKKEAR EAQEAKDRYM EEMADTADAI EMATLDKEMA EERAESLQVE
VDSLKERVEE LSMDLEILRH EISEKGTDGA ASSYQVKQLE EQNSRLKEAL VRMRDLSASE
KQEHVKLQKQ MEKKNTELET LRTQKEKLQE ELKQAEATVD ELKEQVDAAL GSEEMVETLT
ERNLDLEEKV REMRETVTDL EAINEMNDEL QENSRETEME LREQLDLSAA KVREAEKKVE
AAQETVADYQ HTISKYRELT SSLQESNREL VSQQSANTEQ TQQPSAELFD FKIKFAETKA
YAKAIEMELR KMEVAQANRQ VSLLTSFMPD SFLRHGGDHD CILVLLLIPR LICKAELISK
QAHEKFDLSG GLGQGTALRG SPGEQRSFAS GLVYSLGLLQ ATLHKYEQAL NSCSVEVFKR
MGTLYSEMSF HERSLDYFID LLHKDQLDET VQVEPLTKAI KYYQQLYSVH LADQDEDCTV
QLADHIKFTQ GALDCMGVEV ARLRAFLAAG QESSGLAVLL KDLDTSCSDI RQFCKKIRRR
MPGTDVAGVP AALGFGSQVS ESLTECRRQL TRVVAVLQEV AAAGAQMVAP LAEQEGLSAL
KLEDITYKAA EQVFGSQGVN GPELLRQSCS SVITTMNKMA TAMQEGEYDA EKPQGKAPPV
EKRAAIVRAE MTDAEGLGVK LEDRETVIKE LKKSLKIKGE ELSEANVRLS LLEKKLDTST
KDADERVEKI QTKLDDNLAL LKKKEKEFEE TMDALQADID QLEAEKAELK QRIQNQSKMT
IEGLRGSPGS GIASIVQGSA SLPATLAGPT QVVDSPLLRQ QLEVQRLGIK YLKNENNRLK
AEKMKAQLAS LPPLCPPKLP QVSKESSSSP EGLNTGIYRR TDQLLATLLK LSAEVKVVDI
TGKTAVSASA QLLEQTARLK NLKDALDKLQ GEVAEHVVSN QPGAKASSDF ATFPASSFIK
AKEEKQGGTV FVGRVAIPCT RGQEQVHRLV LSQQQLQQVH NLLMV
//
