ID A0A3B5PXD2_XIPMA Unreviewed; 714 AA.
AC A0A3B5PXD2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Sema domain-containing protein {ECO:0000259|PROSITE:PS51004};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000023232.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000023232.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000023232.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; A0A3B5PXD2; -.
DR Ensembl; ENSXMAT00000025720.1; ENSXMAP00000023232.1; ENSXMAG00000021643.1.
DR GeneTree; ENSGT00940000165656; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036:SF135; SEMA DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 659..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..449
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 714 AA; 79683 MW; A56F6411B5215A8F CRC64;
MPVGFFHSDV NLKLFKEPDF NGLSSLLVRE DIGLLFVGAR GKVITLSLDD ITVKTRDYSV
FGIECDNYIR MMHTLDDGRI LVCGTKAFDP TCTHLMFEEG NVTMEDSFQN GRGKVPFDPN
ENFASMVNGN TLYTAGSINF LGTVKSFQRH GRNTLRTEPI WSWLNGPNMI SMKFAEISKH
SNNNEDDNVF LFLTEIKIEA QRSNLRLSRV ARVCKSDLGG LRILQKKWTS FLKARLDCPF
GDEGSASLVQ DVFFLQDENN VTDSIFYATF TLSTTCSQSA VCAYKLSDIQ QVFRGNFMTF
TDSGSWVRYT GTVFSPYPGS CINDEMRASG VRTSRDVPDA TLLFVKNHPL MEQVVTPITG
KPLLVRPTAQ FSKIVVDKVT SLDGEQHNVM FISNNSGWLQ KAVWSGDDGG RIIEDLQLFK
NPQPIRFLQL SRRGQLYSAT RTAVAQLSVR DCSRYTSCAD CLIARDPYCG WDHLKGLCAA
VAGASNFSMY VTLTKTCSLC ATLIIRGFNS FVAGSRTSLM VMLQCAQALI ASIPHIKLFT
HIYLSEEKSR IILMAVLASP TVSKQITDIH LTADVAQFLP CFPDANLPIS WSFSGKILEP
GPRHILLSQG LVLTPSFTDE GLYTCETVEV VKGREHKKAV IQYQVKIGRQ GGRYFSTHLF
PYTLIIVSFG ALGVIHMYKH WTQKSPNHVR CGQCGSDPCT NRTIQGVREG KVYR
//
