ID A0A3B5Q092_XIPMA Unreviewed; 1385 AA.
AC A0A3B5Q092;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Protein 4.1 {ECO:0000256|ARBA:ARBA00023658};
DE AltName: Full=Band 4.1 {ECO:0000256|ARBA:ARBA00030419};
DE AltName: Full=Erythrocyte membrane protein band 4.1 {ECO:0000256|ARBA:ARBA00032586};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000024535.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000024535.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000024535.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR Ensembl; ENSXMAT00000040841.1; ENSXMAP00000024535.1; ENSXMAG00000010314.2.
DR GeneTree; ENSGT00940000157833; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13184; FERM_C_4_1_family; 1.
DR CDD; cd17105; FERM_F1_EPB41; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR021187; EPB4.1_FERM_F1.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF12; PROTEIN 4.1; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 544..825
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 915..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1128..1155
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1385 AA; 159978 MW; B0373DC987B0F460 CRC64;
MATMTTEASA VNEADTEGKQ KSSRAPPEAE SVQQETTATE QEGEQSSKKA QEQAAEPGPV
DVATSPEEEQ LKPRTRTSAG KGLSRLFSSF LKRRSQCSDG EGFEAERASD EKADKEKADN
VEEEKVEEVK SEDKESKIVE EKLDVKEVKK KEEDKIEQKE EKKKVEEKVE KKGSKKKKKE
AKKKAEEKDE GKVKKDEAKK EEEKPEEQKD EKIKTIVEKE EAKPETKVEE KKQVTQIKEK
GTESGKKEEG KVDKKEAKKK EKEEKLKKKE EEKTKRKAEE DERVRKREEE KAKKREEEKA
REVEKLKKKE EVKAKKKEEE KAKEEKTKKK EEEKAKEEKA KKEEEKTKEE KTKKKDEKAK
EDQEKKKEED KPKEEKQEEK VKHLEKTEKE EEKTEETQQK EEEKGKKREK GKDKGKKEDK
EENKPSEEQV KAPIAAPEPE LKLELDTEQA GDHQSVSSAE TQPAPEEQKE EPKVKEELEI
KKEPEVEEEI KEGIEKKKEP TEQQEVTKGE EKTTEKTKKE KPPKQKKTEK KAEEAKGPKR
PKAMQCKVTL LDDTLFECEL DKHAKGQELL TKVCDHVNLL EKDYFGLAIW ETPTGKTWLE
PIKEIRKQVS GGVYEFTFNV KFYPPDPAQL TEDLTRYFLC LQLRKDIMQG VLPCSFVTLS
LLGSYTAQSE LGEYDPEVHG TDYVKDLNLA PGQSKELEEK VMELHRTYRS MSPAQADLLF
LENAKKLAMY GVDLHQAKDL DGVDITLGVC SSGLMVYKDK LRINRFPWPK VLKISYKRSS
FFIKIRASEQ EQYESTIGFK LPNYKASKKL WKVCVEHHTF FRVPSVEPPS SRRFLALGSK
FRYSGRTQAQ TRQASSMIDR PAPRFTRSAS KRLSRNLDGA GDETLQFLQL LSASSRSEAD
DWSLLITTHK SRPSVEFPAR GESEQASSQS REEEQSVTWK GTETVDGGSQ IISEQQHQHL
KEGEWSDLLY RQPSVATVET FDFVEHQAKP SFGYSSSPDP LHKPAPFQQD DWFLYFGRFL
SESEENILSS SKIQSQIRLE ELATSVVKQE ETTEQVIERL QKSVILIDTL TEIEDLEGKL
RKVRDLEERL QEAGEVSERI LRVIEEQLGQ EEVERLRAEE GDLDHVVLQR FMKRMETDED
EVDELEEQIK DVFLKGLVPE EENELNQLDG SLRTKVREIQ KEWQEEQRKF DSSDVSGATS
VVILQKVERR DGKRVMIVDE SGESNGMLEK QTQREVTERR HFGNPAQEEN EDEWYLLFYR
PPVFSPSDES TYLRSVVKRQ VGEEEIKEQP WILQQPALME RVDDWFVLLA GPPRETKYVE
AVAMKEAQMD EGQFVSVVEV SEDYKVEIEE RQMIQETQRE TWMERGTAKT VCAGFALLPC
ILLAC
//
