ID A0A3B5Q209_XIPMA Unreviewed; 1973 AA.
AC A0A3B5Q209;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=SH3 and multiple ankyrin repeat domains 3 {ECO:0000313|Ensembl:ENSXMAP00000025145.1};
GN Name=SHANK3 {ECO:0000313|Ensembl:ENSXMAP00000025145.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000025145.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000025145.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000025145.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000256|ARBA:ARBA00034105}.
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DR Ensembl; ENSXMAT00000037697.1; ENSXMAP00000025145.1; ENSXMAG00000004582.2.
DR GeneTree; ENSGT00940000153561; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR CDD; cd17177; FERM_F0_SHANK3; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09506; SAM_Shank1_2_3; 1.
DR CDD; cd11984; SH3_Shank3; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24135:SF4; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 3; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT REPEAT 261..293
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 328..360
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 361..393
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 588..647
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 688..782
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1910..1973
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1093..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1175..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1246..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1383..1451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1499..1663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1802..1892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..976
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1248..1265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1272..1287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1398..1450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1527..1541
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1572..1588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1589..1621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1841..1863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1874..1890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1973 AA; 214431 MW; D80BCDEF65EB767E CRC64;
MPLRPAAGKH EPPSSPRQDQ QQHTHSRTHT HPYTHAPNGS QGASTDSSSS REEESSVPVP
HAVPAFGPGG EHSNSAGAPM EEPTGNTVVI RIGIPDLQQT KCLKFNVDAP IWLSKQRILC
TLNQSLKDVL NYGLFQPAYN GKAGKFLDEE RQLREYPFPS IAPVPYLEFR YKRRVYTQTY
IDEKQLSKLH TKANLKKFME YVQQRNIEKV SRFLEKGLDP NFHDPDTGEC PLTLAAQLEG
CAELIKVLKN GGAHLDFRTK DGITALHKAV RSKNHTALIT LLDLGASPDY KDSRGLTPLY
HSAMVGGDPY CCELLLHDHA QVGCEDENGW QEVHQACRYG HVQHLEHLLF YGADMSAQNA
SGNTALHVCA LYNQDSCARV LLFRGANKEI KNYNSQTAFQ VAIIAGNFDL AEIIKVHKAS
DVVPFRETPS YTNRRRVVAG TLPSPRSLLR SASDNNLNGD HDHIHPPRPR ESRGRPGHSP
VPSLRSLPAF GQQHSSLGEG RHGEIPDSSL QSTGSSRSSH SRSPSLHHMH EEDRPVPRRS
HSHGYPHGHG PRGRLSPGSV QRDPSPPHHT PPALTGPRGP KRKLYSAVPG RTFIVVKPYT
PQGEGEIQLN RGERVKVLSI GEGGFWEGTV KGRTGWFPAD CVEEVQMRQY DPRLETREDR
NKRLFRHYTV GSYDNFTSYS DYIVEEKNAV LQKKENEGFG FVLRGAKAET PIEEFTPTPA
FPALQYLESV DVEGVAWRAG LRTGDFLIEV NGVNVVKVGH KQVVSLIRQG GSRLLMKVVS
VTRKPESEEI VRKKAPPPPK RAPSTTLTLR SKSMTAELEE LASARRRRGE RLDEMLASQE
SMLHSQPPEA DYRAATVKQR PTSRRITPAE ISSLFERQGM TLHGGLHPGI ERGHIPFPKG
MSRTKSFGAT EEDRLSALAG EHRFPRSSSM TDSLRDHSQP HPIPPPPQTA PPPPPYYLDT
GPPPAFCPPP PPSRTQSQGH EPGGRSSFKP SSLDLPYEAA QRQATHIERQ KKARSMIILQ
DSSHLPVEPT EIPRPSAATP PERIKRKGRV IDNPYANVGQ FSIGLFTPTK PQRKKSPLVK
QLQVEDAQEK ASLALAAAHS RESSPSGRHP HGHTHTSRVD YYQQQLMAER ERLRAQGEMM
FQGKGPFAAA IAGAVKDRER RLEERRKSTV FLSVGTMEGS PTTSPDSPSL TQSHSIDERL
LTRELGQLPP PALALSPSPS GTTFIHPLTG KPLDPNSPLA LALAARERAL TSQSQSPTGS
PEPRTKQERV GQVVMFSDTQ TKESPHGDGV TASPPFSPKS AKAAGYGTSS SPANILAPQA
IKPQWTTSSS PISFRQEMEA RIEERKEEKR LEDKKSMLIS IMDTSQQKTA GLIMVHATSN
GQAAGMGSGI EQKPVPATIE PSKSQSPRAK SPIPTALQPQ TQLQVQPQTQ RPASPAQEKT
LAQGSSEEDA DAYTVTLPPA MLSSSDEETR EELRKIGVVP PPDEFANGLL AQAQGIPVSS
AKAALSPATP ATPTPQTPLT PTTPTVTTTQ PQPPQPPQPP STAAVSGKTS DPLEPPPVGE
AGSAADSGVE EADTRSSSDR ERDHHLETTS TVSTVSSMST LSSESGEPAD THTTHTSYAD
GQTFVLDKPP VPPKPRLKSQ IGGSKGPVTF RDPLLKQSSD SELLSQQQAA ALAAAAAGGA
GLPAGGSASV TGLAPTKPRY LFQRRSKLWG DLVEPRGPGV GLGIGSLGNL GGLGLGLGAD
ESAKPSVMGE LSSRLQQLSK DTRSLGEEPL GASLDPGRKS PVAGARLFSS LGELHTLSQR
SYGTTYTIRP GSRYPVTRRA PSPGSGSPDR GDPLGRFSGF GLPTSPTTPP QTILKSSSLS
LPQEPKEVRF VMRSSSARSR SRSPSPSHSP GLGSPLLALR PFHQKPLHLW NKYDVGDWLE
SINLGEHRAG FQEHEIEGSH LPALTKDDFA ELGVTRVGHR MNIERALKLL LES
//