ID A0A3B5Q2X4_XIPMA Unreviewed; 684 AA.
AC A0A3B5Q2X4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=T-box transcription factor 2 {ECO:0000313|Ensembl:ENSXMAP00000025167.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000025167.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000025167.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000025167.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR AlphaFoldDB; A0A3B5Q2X4; -.
DR STRING; 8083.ENSXMAP00000025167; -.
DR Ensembl; ENSXMAT00000031343.1; ENSXMAP00000025167.1; ENSXMAG00000025936.1.
DR GeneTree; ENSGT00940000158439; -.
DR InParanoid; A0A3B5Q2X4; -.
DR OMA; EQCKPER; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0036302; P:atrioventricular canal development; IEA:Ensembl.
DR GO; GO:0048318; P:axial mesoderm development; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0003205; P:cardiac chamber development; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl.
DR GO; GO:0042074; P:cell migration involved in gastrulation; IEA:Ensembl.
DR GO; GO:0021538; P:epithalamus development; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0070365; P:hepatocyte differentiation; IEA:Ensembl.
DR GO; GO:0072068; P:late distal convoluted tubule development; IEA:Ensembl.
DR GO; GO:0030903; P:notochord development; IEA:Ensembl.
DR GO; GO:0043704; P:photoreceptor cell fate specification; IEA:Ensembl.
DR GO; GO:0021982; P:pineal gland development; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0035777; P:pronephric distal tubule development; IEA:Ensembl.
DR GO; GO:0072019; P:proximal convoluted tubule development; IEA:Ensembl.
DR GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR GO; GO:0046549; P:retinal cone cell development; IEA:Ensembl.
DR GO; GO:0042671; P:retinal cone cell fate determination; IEA:Ensembl.
DR GO; GO:0046548; P:retinal rod cell development; IEA:Ensembl.
DR CDD; cd20188; T-box_TBX2_3-like; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR022582; TBX2/3_TAD.
DR InterPro; IPR048387; TBX2_3_RD.
DR InterPro; IPR002070; TF_Brachyury.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF82; T-BOX TRANSCRIPTION FACTOR TBX2; 1.
DR Pfam; PF00907; T-box; 1.
DR Pfam; PF12598; TBX; 1.
DR Pfam; PF20627; TBX2-3_RD; 1.
DR PRINTS; PR00938; BRACHYURY.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 97..275
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 268..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 74567 MW; 724E3A01F119E622 CRC64;
MRDPVFTGTA MAYHPFHPHR PTDFPMSAFL AAAQPSFFPA LSLPPGALTK PIPEHGLAGA
AEAGLHPALS HHQAAHLRSM KSLEPEEEVD DDPKVTLEAK DLWDQFHKLG TEMVITKSGR
RMFPPFKVRI NGLDKKAKYI LLMDIVAADD CRYKFHNSRW MVAGKADPEM PKRMYIHPDS
PATGEQWMAK PVAFHKLKLT NNISDKHGFT ILNSMHKYQP RFHIVRANDI LKLPYSTFRT
YVFPETEFVA VTAYQNDKIT QLKIDNNPFA KGFRDTGNGR REKRKQLTMP SLRMYEDQCK
ADREGADSDA SSSEPQAGRD AVHSPLGAST SPLRFSRPSR DEKTLTDSEQ ELEQQDERCT
GSNSPGTEPV SPYSSRCEER VRDRPSAEKK DESIFSIRNL EKDKAESRHR KDTTEVLTKD
AEAGGTAATK DTFSPLVVQT ESPSHFSPGH LQSLALSGLH SQQFFNPLST GSPLLFHPGQ
FAMAPGAFSA MGMGHLLASV SGASGLENGS LSAQGTGGTP NPFPFHLSQH MLASQGIPMP
PFGGLFPYPY TYMAAAAAAA SASALPATST SSPLSRNPFL GSSRPRLRFN PYQLPVSLAQ
SSSLLTTGLP SGLSLGNESS KPGSRESSPA PDHHSNHKTG GLGGRVASPK TSMKDSVNEL
QSIQRLVSGL EGQRESSPTA DSPK
//
