ID A0A3B5Q3E7_XIPMA Unreviewed; 651 AA.
AC A0A3B5Q3E7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 6 {ECO:0000256|ARBA:ARBA00020973, ECO:0000256|RuleBase:RU365075};
DE Short=COG complex subunit 6 {ECO:0000256|RuleBase:RU365075};
DE AltName: Full=Component of oligomeric Golgi complex 6 {ECO:0000256|ARBA:ARBA00031348, ECO:0000256|RuleBase:RU365075};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000025332.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000025332.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000025332.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for normal Golgi function.
CC {ECO:0000256|ARBA:ARBA00003627, ECO:0000256|RuleBase:RU365075}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000256|ARBA:ARBA00011166}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395, ECO:0000256|RuleBase:RU365075};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004395,
CC ECO:0000256|RuleBase:RU365075}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000256|ARBA:ARBA00011023,
CC ECO:0000256|RuleBase:RU365075}.
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DR RefSeq; XP_005796882.1; XM_005796825.2.
DR AlphaFoldDB; A0A3B5Q3E7; -.
DR STRING; 8083.ENSXMAP00000025332; -.
DR Ensembl; ENSXMAT00000034701.1; ENSXMAP00000025332.1; ENSXMAG00000007388.2.
DR GeneID; 102237157; -.
DR KEGG; xma:102237157; -.
DR CTD; 57511; -.
DR GeneTree; ENSGT00390000013518; -.
DR InParanoid; A0A3B5Q3E7; -.
DR OMA; HSCLDFF; -.
DR OrthoDB; 276556at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR010490; COG6.
DR InterPro; IPR048369; COG6_C.
DR InterPro; IPR048368; COG6_N.
DR PANTHER; PTHR21506; COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6; 1.
DR PANTHER; PTHR21506:SF0; CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6; 1.
DR Pfam; PF20653; COG6_C; 1.
DR Pfam; PF06419; COG6_N; 1.
DR SMART; SM01087; COG6; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU365075};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365075};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365075};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365075}.
FT DOMAIN 54..165
FT /note="Conserved oligomeric complex COG6 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06419"
FT DOMAIN 199..650
FT /note="Conserved Oligomeric Golgi complex subunit 6 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF20653"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 651 AA; 73351 MW; B656746C88D91D58 CRC64;
MANTKIETSV DNATISSNSN MPSQPNNPLS RKLNKILETR LDNDKEMLEA LKALSVFFTE
NSLRTRRNLR GDIERRSLTI NEEFARIFKE VKEELESVHE DVQAMSTCCE EMTNRLKAAK
EQTQDLIVKT NKLQGENQRL EVRAQVAQAF LAKFQLSNEE MATLRRARDA PVTEDFFKVL
SRVKHIHEDV KILLRTNQQT AGLEIMEQMA VLQETAYEQL YRWAQNECRG LTQETCDISP
VLTQAMEALQ DRPVLYKYTL DEFGTARRCA VVRGFIDALT RGGPGGTPRP IEMHSHDPLR
YVGDMLAWLH QATASEKEHL EALLKQVTLQ GVEENMQEVV GHITEGVCRP LKVRIEQVIV
AEPGAVLLYK LSNLLKFYHH TISSIIGTSV ASMLITIEEM HLLSKKMFFN SLSLHASRLM
DKVELPPPDL GPTASLNQTL TLLREVLTSH DSSVVPLDAR QADFAQVLSC ILDPLLQLCT
VSASNLGTAD MATYMVNSLY VMKTTLALFE FTDKRLEMLE FQIEAHLDTL INEQASYVLT
RAGLSYIYSC VQQHTAEQGP LSLLPSMDVS SVKTAMVQFD RYLSSPDTLV MPQLNFLLSA
AIKEQIFRQS TELVCRAYGE VHMALTSPAN AYKDPENLVP RSPQQVQTLL S
//
