ID A0A3B5Q5Q6_XIPMA Unreviewed; 930 AA.
AC A0A3B5Q5Q6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 08-NOV-2023, entry version 23.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000026197.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000026197.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000026197.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR AlphaFoldDB; A0A3B5Q5Q6; -.
DR Ensembl; ENSXMAT00000039302.1; ENSXMAP00000026197.1; ENSXMAG00000011017.2.
DR GeneTree; ENSGT00940000155295; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF53; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT REPEAT 48..80
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 81..113
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 176..208
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 217..312
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 427..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..510
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..789
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 930 AA; 104308 MW; BB1EBBBEF7D2C8CA CRC64;
MEDLEPEEQF LQCARNGDLP GVQELLRSNA AAERRINVNC KGQSKSNLGW TPLHLACYFG
HKDVVEELLK AGANVNLPNN IGDTALHKAA FTGRKEVVML LLHYDACAAV INGSAQIPKD
VTQNAEIRSM LEAAARTEER KLEEKLLEAA REGDLSTLSQ LLSRKKPPDI NCTDLLGNTP
LHCAAYRGQR LCALKLLRSG ADASAQNKNG EGLTRHVKKY EGLLWKSSRF FGWRSYWVVV
LDGVISWYPK QSDAAANVRR QGCKSLTNAH CLVTKDNCFF TLKCFDDSVH HFKVCPKSEP
EAWLDALEEH SAYSTHYCSQ EQGSEEEEEE EQGMSLGELT DSLQVVVNKD VHNERVGTAV
RSVFCERGAP RRFIPTRAAS LTHLHLSHVS LTHQAAEVRS VKLEQEVEKN KILSEALQTL
ATEHHELEQS VVKGSSPRSA LSEDEFHDAV SESGSELSLS GFETVASNSF EEDEEEDEGS
VMLSSPCSSP ATSMLQEDHH GDRDETQSNG ITKHRASLPA PMFSRNDFSI WSILRNCIGM
ELSKITMPVI FNEPLSFLQR LTEYMEHTYL IHQANSSSES IERMKCVAAF AVSAVASQWE
RTGKPFNPLL GETYELVRDD LGFRLISEQV SHHPPVSAFH AEGLKQDFVF HGSIYPKLKF
WGKSVEAEPK GIITLELPKH SEAYTWTNPT CCVHNIIVGQ LWIEQYGNVE VINHRTGEKC
CLNFKPCGLF GKELHKVEGY ILDKSKKKLC ALYGKWTECL YVVDPAAFEA HKKNDKKGAE
EKKAGKAGKS GDQEGVPSPA SDTVEVIPGS QLLWRIAPRP ANSTQMYSFT SFAMQLNELH
KDMQGVIPQT DCRLRPDIRA MENGDIDLAS EEKKRLEEKQ RAARKNRTKS DEESKPRWFQ
QGPNPHTRSQ DWLFSGGYWD RSYSQLPDIY
//