ID A0A3B5Q5W7_XIPMA Unreviewed; 920 AA.
AC A0A3B5Q5W7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Glutamate receptor 1 {ECO:0000313|Ensembl:ENSXMAP00000026257.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000026257.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000026257.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000026257.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005795484.1; XM_005795427.1.
DR AlphaFoldDB; A0A3B5Q5W7; -.
DR STRING; 8083.ENSXMAP00000026257; -.
DR Ensembl; ENSXMAT00000023514.1; ENSXMAP00000026257.1; ENSXMAG00000010477.2.
DR GeneID; 102221441; -.
DR KEGG; xma:102221441; -.
DR CTD; 798689; -.
DR GeneTree; ENSGT00940000157342; -.
DR InParanoid; A0A3B5Q5W7; -.
DR OMA; DSDIQHS; -.
DR OrthoDB; 511851at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0022824; F:transmitter-gated monoatomic ion channel activity; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR CDD; cd13729; PBP2_iGluR_AMPA_GluR1; 1.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF157; GLUTAMATE RECEPTOR 1; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..920
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017269109"
FT TRANSMEM 535..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 833..855
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 408..808
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 418..483
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 571..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 920 AA; 102477 MW; 119508D0422C9917 CRC64;
MQRSFTLLYT SLLGICLGSG SSFPSNINIG GLFPNVSHEY EVFRFALSHH QDIPKLVSHV
DMVIMGNSFS MTYAFCSQFS KGVYAIIGLY DRKTVNMLMS FCGALHVCFV TPSFPIETAN
QFVIQLRPEL QDALVGVIEH YGWNKFVYMY SSDSGLSVLQ KVLDTAAEKN WLVTSVNVES
MTGDSFMKVF KDLDKWKEGN IIIDCETERL TGILKEIVEQ GKNAKSFHYI LANLGFLDID
LTDLRKGGAN ITGFQLVNNS EPSVSRIVQQ WMEFDNKDSK MPKTGLKYMG ALTYDGVKVM
STAFQYLRRQ RIDISRRGNA GECLANPPAP WGQGIDIQRA LQQVQIDGLT GHIQFNEKGR
RTNYTVCVME LAPSGPKKVG YWNEDEKYVS TASLSRVNND THGLLNRTYI VTTILESPYV
MLKKNHDLLV GNDKYEGYIV ELAAEIAKHV GYQYKLKIVS DGKYGAKDPE TQKWNGMVGE
LVYDKADLAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PTKSKPGVFS FLDPLAYEIW
MCIVFAYIGV SVVLFLVSRF SPYEWHAEDY EEGAEPQTPT QAAASNGVQP SQTPTQQNAN
QQSPEQTNEF GIFNSLWFSL GAFMQQGCDI SPRSLSGRIV GGVWWFFTLI IISSYTANLA
AFLTVERMVS PIESAEDLAK QTEIAYGTLD AGSTKEFFRR SKIAVFEKMW SYMKSADPSV
FVKTTDEGVM RVRKSKGKYA YLLESTMNEY IEQRKPCDTM KVGGNLDSKG YGIATPKRSP
LRNPVNLAVL KLNEQGLLDK LKNKWWYDKG ECGSGGGDSK DKTSALSLSN VAGVFYILIG
GLGLAMLVAL VEFCYKSRTE SRRMKQSIND AMRCSTLTRM SGNGSGGENG RILTHDFPKT
VQTLPCMSHT ASMGLGTSGM
//
