ID A0A3B5Q7C0_XIPMA Unreviewed; 146 AA.
AC A0A3B5Q7C0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Thyrotropin subunit beta {ECO:0000256|ARBA:ARBA00039483};
DE AltName: Full=Thyroid-stimulating hormone subunit beta {ECO:0000256|ARBA:ARBA00042284};
DE AltName: Full=Thyrotropin beta chain {ECO:0000256|ARBA:ARBA00042931};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000026767.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000026767.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000026767.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC which confers biological specificity to thyrotropin, lutropin,
CC follitropin and gonadotropin. {ECO:0000256|ARBA:ARBA00038688}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000256|ARBA:ARBA00006552}.
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DR RefSeq; XP_014329902.1; XM_014474416.1.
DR AlphaFoldDB; A0A3B5Q7C0; -.
DR STRING; 8083.ENSXMAP00000026767; -.
DR Ensembl; ENSXMAT00000039101.1; ENSXMAP00000026767.1; ENSXMAG00000027462.1.
DR GeneID; 102231810; -.
DR KEGG; xma:102231810; -.
DR CTD; 353223; -.
DR GeneTree; ENSGT00940000158152; -.
DR InParanoid; A0A3B5Q7C0; -.
DR OMA; MCLPTEF; -.
DR OrthoDB; 5353873at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR PANTHER; PTHR11515; GLYCOPROTEIN HORMONE BETA CHAIN; 1.
DR PANTHER; PTHR11515:SF5; THYROTROPIN SUBUNIT BETA; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..146
FT /note="Thyrotropin subunit beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017342069"
FT DOMAIN 20..120
FT /note="Glycoprotein hormone subunit beta"
FT /evidence="ECO:0000259|Pfam:PF00007"
SQ SEQUENCE 146 AA; 16746 MW; 30970A3404BDD5D2 CRC64;
METSAFSCWV LFLLIYPVVP MCLPTEFTLF VEKPECDYCV AINTTICMGV CFTRDSNMRD
IFRSRFVVQR SCTYDKVEYR TVILPGCAID SNPAYTYPVA ISCHCGACRT DRDECTLRLN
SYDANCAKPV RRVYPYPGQS NYMIPF
//
