ID A0A3B5QB32_XIPMA Unreviewed; 653 AA.
AC A0A3B5QB32;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=TBC1 domain family member 23 {ECO:0000256|ARBA:ARBA00014207};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000027459.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000027459.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000027459.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC {ECO:0000256|ARBA:ARBA00004601}.
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DR AlphaFoldDB; A0A3B5QB32; -.
DR Ensembl; ENSXMAT00000024236.1; ENSXMAP00000027459.1; ENSXMAG00000015938.2.
DR GeneTree; ENSGT00390000000191; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd20788; TBC1D23_C-like; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR039755; TBC1D23.
DR InterPro; IPR045799; TBC1D23_C.
DR PANTHER; PTHR13297:SF5; TBC1 DOMAIN FAMILY MEMBER 23; 1.
DR PANTHER; PTHR13297; UNCHARACTERIZED; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR Pfam; PF19430; TBC1D23_C; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 38..219
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT DOMAIN 328..437
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 653 AA; 73163 MW; 3DBBEC2CEFEC82AF CRC64;
MADTVEEAQG SWDQDLAEAL DSGGSDSEME RGIMQIQEHS VEHKAKMWKI ALNVSGKGDS
LSPWDGVLDL PEQTLIHNRS QQLIDQLGVS EEERGEMVSD VESVITFYCK SRNITFTPEL
SLPHLLKPLL GLKLPRSDLY NCFYAIVNKY IPRECVPKGR PFHLYRLLLQ YHEPELCSFL
DTKKITPDSY AISWLGSLFS SHCSPEVTQA LWDSYLQQAD PFLIFFLMLI ILVNAKETIL
AEEAESKEDI IKMLEMSPSL LEAEDIEDLF SLAQHYQSKT PLSLRKMNQN LFGSSLVALK
EEDTDLSQAL CLPVSVPEIL QANQLQQDGV RFFVVDCRPA EQYNAGHLST AFHLDSDLML
QNPSEFALSV KSLLEAQKQS LESGSIASGE HLCFMGSGRE EEDMYMNMVL AHFLQKNKEY
VSIAKGGFMA LQKHLVDMNV EGLDSSYMNW IVSTSGSHSS LSSVDGESLS SPGDGKGVKS
LVNKMTFALK SKSVNVKEKM ISFIENTSTP VDRHVSSSDR VGKPYRGVKP VFSIGDEEEY
DTDEIDSSSM SDDDRKEIVN IQTWINKPDV KHHIPCNEVK ETGHMFPSHL LITATHMYCL
REIASRKGFA YIQSRQALSS VVKITSKKKH PELITFKFGT NNSAGVEISA VER
//
