ID A0A3B5QBX9_XIPMA Unreviewed; 224 AA.
AC A0A3B5QBX9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Metalloproteinase inhibitor 4 {ECO:0000256|ARBA:ARBA00013515};
DE AltName: Full=Tissue inhibitor of metalloproteinases 4 {ECO:0000256|ARBA:ARBA00030105};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000027721.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000027721.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000027721.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protease inhibitor I35 (TIMP) family.
CC {ECO:0000256|ARBA:ARBA00011027}.
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DR RefSeq; XP_005797014.1; XM_005796957.1.
DR AlphaFoldDB; A0A3B5QBX9; -.
DR STRING; 8083.ENSXMAP00000027721; -.
DR Ensembl; ENSXMAT00000021019.1; ENSXMAP00000027721.1; ENSXMAG00000028986.1.
DR GeneID; 102229473; -.
DR KEGG; xma:102229473; -.
DR CTD; 7079; -.
DR GeneTree; ENSGT00940000159798; -.
DR InParanoid; A0A3B5QBX9; -.
DR OMA; ITTPNEC; -.
DR OrthoDB; 5403389at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd03585; NTR_TIMP; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 3.90.370.10; Tissue inhibitor of metalloproteinase-1. Chain B, domain 1; 1.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR001820; TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR InterPro; IPR027465; TIMP_C.
DR InterPro; IPR030490; TIMP_CS.
DR PANTHER; PTHR11844; METALLOPROTEASE INHIBITOR; 1.
DR PANTHER; PTHR11844:SF26; METALLOPROTEINASE INHIBITOR 4; 1.
DR Pfam; PF00965; TIMP; 1.
DR SMART; SM00206; NTR; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50189; NTR; 1.
DR PROSITE; PS00288; TIMP; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601820-3};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601820-1};
KW Metalloenzyme inhibitor {ECO:0000256|ARBA:ARBA00023215};
KW Metalloprotease inhibitor {ECO:0000256|ARBA:ARBA00022608};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR601820-1}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..224
FT /note="Metalloproteinase inhibitor 4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017469239"
FT DOMAIN 30..156
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT BINDING 30
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="ligand shared with metalloproteinase partner"
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-1"
FT DISULFID 30..102
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 32..131
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 42..156
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 158..205
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 163..168
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 176..197
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
SQ SEQUENCE 224 AA; 25058 MW; 8D9839DA7A4B6143 CRC64;
MALSQERSAC LGLVVLLLLG AGMEDVVEGC SCHPSHPQQL FCSAEIVIRA KISGEKIVSP
SNSSSPYMKM IQYEIKMIKM FKGFDRAKDI QYVYTPVYSS LCGVKLDSNN KAGYLLSGSM
WSDGRISIGQ CDLVESWDNL SLSQKKNLNY RYQMGCECRI NTCYTVPCAS TGENECLWTD
WLLDNSLNGE QARQYACIRR SDTSCGWYRG GPPPEKDFLD MTDP
//
