ID A0A3B5QCS0_XIPMA Unreviewed; 1001 AA.
AC A0A3B5QCS0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000028036.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000028036.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000028036.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; A0A3B5QCS0; -.
DR STRING; 8083.ENSXMAP00000028036; -.
DR Ensembl; ENSXMAT00000040874.1; ENSXMAP00000028036.1; ENSXMAG00000000754.2.
DR GeneTree; ENSGT00940000157182; -.
DR InParanoid; A0A3B5QCS0; -.
DR OMA; NIGIWYN; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF87; ANOCTAMIN; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 372..396
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 449..465
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 532..558
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 578..602
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 622..643
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 747..770
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 92..358
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 361..937
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1001 AA; 115279 MW; 9EFB6956257A4422 CRC64;
MEQQEEQVGG LSHHGSSQEF GSPSISSFEP GESSQQEEGT VMMRSENYLP VPGEDKNLDG
DFNGKTTNDK SVPMKTLYAS DGSLLHLPLG PYFSDGQRRV DYVLTYGIQK PSAVRRQSSK
LSDNGLFHWL RHSLCSRSSR APLQPKEDPE VAATEQQANY HEDDKRLKRE EFEQNLQEMG
LELEKDEGGK IAGIGFLKIH APWAVLCREA EIMKLKMPTK QVYEVKQGSN LVEKIRLFIH
KVTDPLHPKV GPKRPGDAKS LSLPFSKEKQ HLFDLSDRDK FFDSKTRSSI VYEVLKRIRW
TRPNYSFGIT SLLANGVYTS AYPLHDGDIE GVTAEPNDRK LLFEEWASYS VFYKYQPIGL
IRKYFGEKVG LYFAWLGVYT QMLIPAAIVG VIVFLYGCAT VDDNIPSMEI CDPRNNITMC
PLCDSVCSYW KLETACGTAR ASHLFDNPAT VFFSIFMALW AVLFMEHWKR RQMRLNYVWD
LTDYGMEEEE HYKDHNRAEY ELRVAEKTMR QDQEGPKDEK VKLTCTDRMP AYLTTVVMMG
FMIFVTLVIT FGVILYRISI KTALHLSTYP AARSNIRATV KTTAAIINLV VIIILDEIYA
LIARWLTTLE VPKTDKSFEE RLIFKTFILK FVNAFTPIVY LAFFRGRLVG RPGKYLYVVG
SYRMEECAHA GCLMELCIQL CITMLGKQLI QNNLFEIGIP KLKKLLRKRK SELTSKQEEE
LHKTLKCYEK DHVLGPFVGI NPEYMEMIIQ FGMVTLFVAS FPLAPLFALL NNIIEIRLDA
KKFVLELRRP IAAKAKDIGI WYNLLRGLSK VAVIVNAFVI AFTSDFVPRL VYQYTYSPDG
TMHGFVNHTL SYFNVSDFQK GTEPSIPKFD VKVCRYKDYR EPPWSNTPYE LSKEFWAILA
VRLAFVIVFQ NVVMLMSDFV DWLIPDIPKD ISFQIHKEKL LMLDHFMKEE GRRRDNYNHD
GYNSPSSDSR RNHQMNCLLC RKTWTSTSFS NIWSEEVFQP F
//
