ID A0A3B5QF74_XIPMA Unreviewed; 1776 AA.
AC A0A3B5QF74;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Ral GTPase activating protein catalytic alpha subunit 2 {ECO:0000313|Ensembl:ENSXMAP00000029002.1};
GN Name=RALGAPA2 {ECO:0000313|Ensembl:ENSXMAP00000029002.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000029002.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000029002.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000029002.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSXMAT00000034096.1; ENSXMAP00000029002.1; ENSXMAG00000019065.2.
DR GeneTree; ENSGT00950000183139; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR046859; RGPA/RALGAPB_N.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR PANTHER; PTHR10063:SF2; RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-2; 1.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR Pfam; PF20412; RALGAPB_N; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 1536..1744
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 336..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1452..1482
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 339..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1776 AA; 200834 MW; C89C12273E85B30C CRC64;
MFTRRGHGDV KKSTQKVLDP KKDVLTRQKH LRALIDIIDK GELKAFFESN CSQIYFIFYE
NFITLESSLK QKGKYPACLF HLNFGFQKYL NVFFFFFSFS GSILKKLLHT GNSFKIRCEG
IRLFLLWLQA LRDNCAEEQF LIFACLVPGF PAVPSSRGPC TLDSIINNPS SNTLEAKVVP
EEITPLVPAV SGEKVADDLT CYFLETLLKY MVIQASSLEW KNKENEDTGF RFLFSLFKKY
YLPHLFPSFT KFTNLYKPLL ELPPLRAKPL YVPVTRNNES TFCTRDQYLA PRVAFITWLV
TFFLEKKYIN SAAAAQSAKN GTEVIPKLIQ VNMIGPPGDT EKSHSNSSTL SDRRPSDSSL
CSIEEEHKHV YDMVHGILLS TRDNVNFVNE VFHQAFLLPA CEASATRKVI KVYRKWLLQE
KPIFMTEPDP TTQEDEVDEN SERVLSTDAF ESHGHKRSSS WGRTYSFSSA INRGFLTEEQ
NRDVKAGMQL TLQVFLTNSS NVFLLEPCQD VPKLLENQVE VCKNVLSIYR HMIMEHSMTT
QTWLQMLQVL LKITEAVMKR PQENQRKDSF AESLASLLFR TIIVAWVRAN LSVFISRELW
DELLAVLSSL TCWEELVMEW ASIMDSLTAV LARSVYGLDM ANLPLDKLSE QKEKKQRGRG
VIQDSQKAAA VARSFSLSWR NHGEQGGPVA QEPMRIRSAT TSGAPGVEKA RNNVRQKASG
QYDPRSTSSS TPLAFIKLFP HVRCFTVLTR NINQHCESVS SETSNGYLNE AEVTWQTFDE
EADTQSTQSA HMDVTADPQN QGSLLLSHND ALADSSECLA DDVSIIAGGT LTGWHPDSAF
VLWRRILGIL GDVNNIRCPK IHAKVFSHLY DLWHKLAKER TLIMDNQSSP PQPVFIPPLR
MLASWLFRAT MLQAEYKAGK LQAYKLICEM MTRHQDVLPN SDFLVHLYHV MHKGFTSHDQ
DILNTIVRSC SPRFFFLGLP GFTMLLGDFI TAAARVLSSD SKEAPRIEAQ TVLGSLVCFP
NLYLQIPVLH CVPGSNDISV GNEDIKNYLV RNLLDAATKE YCEGARCIAV CSLGLWVCEE
LMQKNIHHQV KDAINVLGVT LKFGNKVVAQ VACDMFHLLI SHWEHLQRLD PTLPKKIIEI
FVATIAFLLP SAEHSTVEAD KKMMVSLLLC LLDWCMAVPL SLLLEPITKS SLEPHSPIKA
PLLDYIYRVL HCCVSGSNLH TQQSHYLLSL SDLSNEYDLM LGQVKSFEPP PSQMTTADFG
NLLTVAEEKR RRNMELIPLT ARMVMTHLVN HLGHHPLSGG PALLHSLVSE NHDNPYVESS
ELSSEVFKSP NLQLFVFNDS TLVSYLQIPA EAPTAGQPPH PSSQVRIIVR DISGKYSWDG
TILYCTARNQ PTSPLKGHYK THCSVSDSLS NFCEEDEVDV LDKLLEDLSH SSPECLPQPR
LQLNQPAPSP HGMNLEQEKA ILEAILRQTE QEEEQVRKWD ADVSFRAACQ REPSHQEPKA
PFYFCRLLLN DLGMNSWDRR KSFHLLKKNS KLLRELKNLD SRQCRETHKI AVFYIREGQE
DKCSILSNYA GSQAYEDFVS GLGWEVDLAT HCGFMGGLQR NGSTGLTAPY YATSTVEVIF
HVSTRMPSDS DDCLTKKLRH LGNDEVHIVW SEHTRDYRCG IIPTDFGDVL IIIYPMKNHM
YFIQIIKKPQ VPFFGPLFNG AIVTGSLLPS LVRATCINAS RAVKSRLTLY QSFYEERALY
LEAIVQNHRE VMTFEDFASQ VFSPSPSYSA SGTGER
//
