ID A0A3B5QG52_XIPMA Unreviewed; 1663 AA.
AC A0A3B5QG52;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Complement C4-B-like {ECO:0000313|Ensembl:ENSXMAP00000029382.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000029382.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000029382.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000029382.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR Ensembl; ENSXMAT00000027170.1; ENSXMAP00000029382.1; ENSXMAG00000015081.2.
DR GeneTree; ENSGT00940000155739; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF144; COMPLEMENT C4-B; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 633..672
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 1512..1661
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 1663 AA; 186968 MW; 3E18E067046EEB2F CRC64;
VSCLLLALTM PLKDTTKSKC HQFVHRFFIS APSVFHVGAK EKVLVQMGGR YLNKLVSVYL
EDQGILMSEK NETRCSSEND IKIVELMKRS SEKPYLELVA EVFDDRIRKI TKVLVSDHSG
YIFIQTDQPM YKPTQKVNYR IFTLNHMFRP HPGTVCISVF NAAGNKIMKT WRKTDGGIFK
GNFPIPSVSK SGTFKITAHY EDDEAKAAVR EFKVQKFVLP SFEVSIETEQ RYILLNDQQF
VFTISAMYSY GERVKGAYHC QFGFITKGEK APHIISGLEL TGSVIDGRAT ATLQLKNIDW
KQLNQTLSDL QSSGSQLYVG VFVTNIQNGE VQEEKLYLPI FPHKYSIDLS RTRSYFIPRY
PVEVVAVVRN PDGTPAVGVP VNISIGSEQT AGITNEHGGV YSAFNFNPTS LVLAGGLQKS
KIIKPASSPT GSYLYISFTN KVYHVGESLS LTFRTPTVPN NSGHIYYMVL SRGTIITKGS
LRHGTLAAGS VSITADMVPF FRLIGYYHGD NGDIIADSVW VDVSDECEIK VTVQHNRQPI
PGKQVSLEIN LHGQTAKVAL LAVDKAFYGL KADNKLTAKQ IFSTMASYDL GCTYSGGSDS
AEVLINAGLS FTSEAKSAWR QGKKFEDAEL QICCTHAFSH IPMNEHTCET RSRRVLLVKN
NQTCADAFLK CCLAAEKLRK KKMREDVQIG LGRTATTEDI EEFFLDTASQ YIRHYFPPSF
EFKEFLVTGK KSHFLALPDS ITTWEIQVVT LSSETGLCVA KPHEIRAFKE SFVSLRLPYS
VKRFEQLSIS PVIYNYGEND LRVAVHMEQT EGFCSPASAT TTSFTEITVK NHSSQFVSFS
VVPMVTGSLP IKIRLYDIER ERGIDALEKN LNVKTEGLVH REEKTEVFYL DGRSSRTIYV
DGTLPDNTVP DTNSNIFISM EGNGFGESHV KNLLSPEIVS RLIVLPTGCL EQTMVRLAPT
TLAIRYLDLS DQWFDLKAGT RDDAFDKIEH GYIKILTYKK PDGSYGAWGS VPSSNWVTAL
VVKVLSLVAE RQTDGQGARG RLLKVVPEEE IHHPVRYLMS VQQSDGSFRD PEPVLHRHVL
KGKDHDAAMT AFITLALIRS LPFHTSENRN KEAAIRKATT YLTSQLEELS HTYAVAITAY
CLSVDQPKKN NQLRAWEKLQ SMVKTGMYKN GCYMWTNSIG PEMQKAVTIE TTAYALLAAV
KNNNTHWANL TACWLVRHEN YLGGFLSGQD TIVALEALSE YELAKTTGSI IDVTAEFTTS
EKNDIIELQL TNVKEKVETE LQKLGGKNIT VVLRGQGNIK LKTVKAYHLL DPEDDCSKLN
ISVKVEGKVK YTANIIENYD YYDDYDASEG KQIREAPSAI ERFDALTQSR RDLENDVNSD
SVVTYTVCVS YNPNSPLTGM GIADITLLSG FEVKVEDLER LKELPEQYIS HYELSSGRLL
MYFNKLFENR ECVSFTANQM VPMGLLQPAS AVFYDYYEPD VKCTVFYSPS RRSKLVSTLC
SEDVCQCAER PCHKVQETFK SNRVKNIKKN TRSEYACFSP RVDYAYILEV QDISVKSNFE
LYNTKVVDIL KFHGDLLVTI NSVRVFAKRL QCKGQLELGR QYLIMGKDGS TKDLTGNMQY
LLESNTWVEK KPLDTDCRKS ANNRTCNEFN QFIDEYKTDG CRQ
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