ID A0A3B5QGA2_XIPMA Unreviewed; 892 AA.
AC A0A3B5QGA2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Prickle-like protein 2 {ECO:0000313|Ensembl:ENSXMAP00000029991.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000029991.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000029991.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000029991.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the prickle / espinas / testin family.
CC {ECO:0000256|ARBA:ARBA00008268}.
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DR RefSeq; XP_005801745.1; XM_005801688.2.
DR AlphaFoldDB; A0A3B5QGA2; -.
DR STRING; 8083.ENSXMAP00000029991; -.
DR Ensembl; ENSXMAT00000021044.1; ENSXMAP00000029991.1; ENSXMAG00000029369.1.
DR GeneTree; ENSGT00940000153629; -.
DR InParanoid; A0A3B5QGA2; -.
DR OMA; YEGPQRE; -.
DR OrthoDB; 370973at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd09415; LIM1_Prickle; 1.
DR CDD; cd09418; LIM2_Prickle; 1.
DR CDD; cd09420; LIM3_Prickle; 1.
DR CDD; cd09827; PET_Prickle; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR InterPro; IPR033725; LIM1_prickle.
DR InterPro; IPR033726; LIM2_prickle.
DR InterPro; IPR033727; LIM3_prickle.
DR InterPro; IPR010442; PET_domain.
DR InterPro; IPR033723; PET_prickle.
DR InterPro; IPR047120; Pk/Esn/Tes.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24211; LIM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24211:SF18; PRICKLE-LIKE PROTEIN 2; 1.
DR Pfam; PF00412; LIM; 3.
DR Pfam; PF06297; PET; 1.
DR SMART; SM00132; LIM; 3.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
DR PROSITE; PS51303; PET; 1.
PE 3: Inferred from homology;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 14..122
FT /note="PET"
FT /evidence="ECO:0000259|PROSITE:PS51303"
FT DOMAIN 124..189
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 190..249
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 310..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..728
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 892 AA; 100773 MW; 6D02F39A28CF2E6F CRC64;
MSLEMEKTIT KLMYDFQRNS TSDDDSGCAL EEYAWVPPGL NPEQVHQYYN SLPEEKVPYI
NSPGEKYRIK QLLHQLPPHD NEVRYCNALD EEEKRELKIF SNQRKKDNLG RGNVRPFPLT
VTGMVCEKCG GQINGGEIVV FAARAGHGKC WHPACFVCCT CEELLVDLIY FLQDGKIYCG
RHHSERLKPR CCACDELIFA DECTEAEGRH WHMKHFCCYE CETTLGGQRY IMKDGRPHCC
NCFESLYAEY CDACGEHIGI DQGQMTYDGQ HWHATEECFC CARCKRSLLG RPFLPKQGQI
FCSRSCSAGQ DPEESDSSDS AFQSARSRES RHSTKIGKKE RRNAEQDRRS TEPRQSAPPP
MPDRLSAEID PLSVPMDRLS LSSSQTPSRT PNRTPSRTPS RAPSLNQVWM SRDEPYIPAS
YEGPKRDPSP TPASIHLLGQ CNARQGYNPN TNAHPPAQSP ANPGKRPDSW GKEQGNAKRT
PMAALRGHSF NENWIHHSQD EFRPNKLRTQ MSFNEMSSQN QGFSDKRSTS LHGFQRDGRP
PLTRRNHITA MSFNEPLTPL EQTPRGSMDS ITMSNTAGNS LDGATKRQEH LSRFSMPDLS
KDSGVNVSEK SNMGTLSSSV QFHSTESLSS SRPYNNNMYT PLRVGYPLQY WEGPQDVGCD
GKGRVGLMGS SGNLRMAPMS DRMPRRRINA QESISQQQQP QPRPHKHHRG TNGHHRSGRH
HKRSRRSRSD NALHLVADRP TQMVELPYRR VQEDYDRFPS GQAARELYGV DSSGHRQMPH
RPCPRTTSDL TLQNAGWQPV GLGGPCWNDG YMEAADPWCS SCSSSSESEA DEGYYLSDPI
PRPVQLCYIN NEELRHRYSP SGIGAHHGPL HGPIHGQLHS RQRRKSKNCI IS
//
