ID A0A3B5QGE1_XIPMA Unreviewed; 1121 AA.
AC A0A3B5QGE1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Neural cell adhesion molecule L1-like protein {ECO:0000313|Ensembl:ENSXMAP00000029477.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000029477.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000029477.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000029477.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR Ensembl; ENSXMAT00000033874.1; ENSXMAP00000029477.1; ENSXMAG00000011144.2.
DR Ensembl; ENSXMAT00000037694.1; ENSXMAP00000028704.1; ENSXMAG00000011144.2.
DR GeneTree; ENSGT00940000165371; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF51; NEURAL CELL ADHESION MOLECULE L1-LIKE PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1121
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041167253"
FT TRANSMEM 1045..1067
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..124
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 129..219
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 244..331
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 336..423
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 429..515
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 519..612
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 619..714
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 719..812
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 829..931
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 932..1033
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 699..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1121 AA; 126172 MW; F9527ADB70C41ADC CRC64;
MRRPGDLLLV LLWTFTSRAR SLNIPFEVEQ PPTITNHTAG PIIALPFDNT LTIRCEARGN
PPPAYTWTKD GQELNLPNIP TVKTDNRNGT FMFHNKHFAQ FRGKYRCFAS NKLGTAMTEE
IEIVLSTSPK FPKETFDTIV VKEGYPITLH CNPPEGVAPR QIYWMTHGLQ HIKQDERVSM
GTDGNLYFAY ALPQDSRKDY GCVAAFQRIR TIVQKTPLSV KVERLEPENN SSESVSATLP
VRAPSLLLPS GVQTEKLLLK GQDLHLECIP AGYPTPKITW MKMGETLTDR TKLDNFKKLL
TISAVDEKDQ GKYMCMAENS AGKADHYFDV IVEEPPSWRT KPPQNQLSVI GSDVFIKCSV
DGKPTPVITW RKNGKILQDD RENNRRVLDE TVMLHKAGPE DSGVYQCEAS NPHGSVLANI
NVLVMNMAPL MLTKDFQEYA VIEGEDIVMN CSVFSSPPSS VSWTKEGTVV EGERFHVLEN
GQFLKIIRSE KGDMGIYACM ASNREGMSNL TALLDVKDPT KIVAPPQDVQ ISSGKLARLM
CRSEYDRSLQ GTFEVIWRKD GEEIFRSSEN SFRYNMEGDQ LQIRDLNISD QGMYTCIART
SLDEDTATAF LTVLDTPDAP MSLKISDQES RNVTLSWIPG SDHNSSVREF VVEYEESHWE
PGRWKELQKV TGNQATAELF LHGDLNYQFR VYAVNAIGPG PPSEPTERLK TPPAAPDRNP
ENIRIHGHFP HEMDISWDPL LPIEFNGPGL EYKISYRKLE VEDKWQEHLV TRPSFIVRNT
STFAPYEIKI QSRNSLGWGP EPRPITGYSG EDIVFWHCLQ ENVSVPTAAP HNVAVEVINT
TVLRVSWSPV LPATVRGHFG GYNVNWERMK SFLSPDKILE EHKSKSFPGN RTHVIVPGFE
PFSEYRLTVN VFNKKGKGPK SDPVNFYTPE GVPEKVPVLF PRIQDDDTVL LEWGPPSVTN
GILTGYFLKY HLLNKTSLEV IDSFELNLTL PDVTQHQIVR SDRGNLFRFY LSACTRAGCG
PAELAENHSP PEKVGTEAST STQRWLIGTL CAVALLTLLA VIVCFVMKTK GGKYAVKEKE
DLFPDAESQA MNDDAYEYSK PHTHDVYQDQ PESQCTHHLM G
//
