ID A0A3B5QL62_XIPMA Unreviewed; 2296 AA.
AC A0A3B5QL62;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Desmoplakin {ECO:0000313|Ensembl:ENSXMAP00000030970.1};
GN Name=DSP {ECO:0000313|Ensembl:ENSXMAP00000030970.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000030970.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000030970.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000030970.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004236}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 8083.ENSXMAP00000030970; -.
DR Ensembl; ENSXMAT00000029672.1; ENSXMAP00000030970.1; ENSXMAG00000016816.2.
DR GeneTree; ENSGT00940000154843; -.
DR InParanoid; A0A3B5QL62; -.
DR OMA; ETKERKC; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002934; P:desmosome organization; IEA:Ensembl.
DR GO; GO:0061436; P:establishment of skin barrier; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 2.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR23169:SF26; DESMOPLAKIN; 1.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR Pfam; PF00681; Plectin; 5.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00250; PLEC; 12.
DR SMART; SM00150; SPEC; 4.
DR SUPFAM; SSF75399; Plakin repeat; 3.
DR SUPFAM; SSF46966; Spectrin repeat; 2.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 297..362
FT /note="Desmoplakin SH3"
FT /evidence="ECO:0000259|Pfam:PF17902"
FT DOMAIN 397..474
FT /note="Desmoplakin spectrin-like"
FT /evidence="ECO:0000259|Pfam:PF18373"
FT REGION 2244..2296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 154..188
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 231..290
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 861..1035
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1062..1414
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1492..1614
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2296 AA; 264880 MW; CD6B39997FA2756E CRC64;
MLRHRLGGYG TMKSHKVSVS SGGSVGNDGG RYFSEAIPWI TQQKRLIETA PFGEDTNTIE
NQIVAHSKVH SSIQTSLEVR RARDDLMAMG NKYHLNILEQ EMDALQKMSS NRLNQLRDLQ
NIIEEVSRAI MWVNGKEEEE LMFDWGDKNI DQYIPRKQES YSKLMSDLEE KEKELNRLKI
KSGALLNSNH PAKDKIEAYV DTLQTQWSWL LQITKCIQVH LKENSAYSQF FKEANETYAK
LQKQHDTIKS KFICDKNTRV ENLIELLKNL EREKERIMEN KRQVQSLVNK SQSIVRLKPR
NPEEKSTTPI MVQALCDFKQ DQKSILKDNQ GILKDNSQRS KWLVTGPGGL DMWIPSVCLL
IPPPNPLSIG IAKKNEQYYE AIMGIWNQLF INIKSLISWQ YCIRDVNYIN SLTISMLSKM
RPDEYRELIK NMEVHYQEFM RSSQGSELFG EEDRKTMQGH FNKAQEHYDT LIIQMPNYSK
EEFFPVKQPT KTNTVISLSL LSNLQEIRRR LEMAESDLTD HLHIPLGENS VHECSVYIQK
LHGVNQDLDS IYNDYLHLRE MITKQLSGLP ADSEQAKFLR SELEIVNHKL GELQHLNKVY
LDRLNALKDM LQKSLQAEDF IKVHEIRLME KETSSDDPQE LEIHWSALRS MKSELDQRRD
LLTAMESDLA KAQYSNNQIS DSFHKCDVDL SKYSELMNQL SNRWRQIQKQ IDIRLSDLEK
QKQQLTQYQQ GRNLMEQWID NTRKRQETLK MANITDRQTL TDHINQQKAL HNEIKNRKDR
LDDVLRNADT CATSIKNYEL ELASYSSGLG TLLNVPVKRT LLQSPASSVR REAGELQTHY
IELLTRSSDY YKFLGDLGKN IDELKLRNTR IELLEEQLRR LQDELDDQKQ KYGSLEGTLA
NYKMELSQAK DELISVQEVK RTTVMQVNAA KENLDSTQGQ MQRLTEELSH IKYQLEEEKR
KRKLAEERFT CHQQECDAST RSRMQELDAM NWTKINLEKS VKDKEHEIER LRMQLEEEER
RRQKVESDIS KVRTQCTQEI SQLKQTYETE IQVSKTTILK VSQQKDEDAS QLRLQVDRLT
DEKRNLEEEL RRQRQSIAVI EMHKSKAEQE ASQQMASVNE ATRIRTNLEL QLRTLQQQRD
EENLKLQESN RNSQEMSRQI SELAFNLQEE EKKRRALELE SSQLKKATAE LMAKNSAYLE
TINTLKGAEQ EVHITRVELE KQTSEKTKAE QSSTRLQSRI RELQCSLDGV EAELDKQKKA
TQEEFTRRKR MEAELERMTS TCREHTTTIN SLKSVQIEVT NTGRKYEQDI KALQEKLDRS
LRDCKVTKEE LTAVTNELKI LKQKLQQEQV RVHELNQRNE SLYKTIEEKS RQLNEYTTEI
EKLKTLTQNL TKERLRLEEE LRAVRQERDE LKISRGAIDT ESATQISALN VQLQTSSKRT
SELQFFISDL TKEREKLKME IEKFQKQSIE TSKLAHDSQS KYTGLVLERD SLLSKLKMLE
QDKNRNQRLE EELGRIKFSL ETELRNKQHL QDERDAIHKE LTSMKSQYES REFQIRQCES
DKGKADRDRL SLNSEIERLR REMHILEETY KRRLVISEKE ASDLALKRDA LEREILRLKR
PAMFNIQTQT DEKIMTIDPS KLGIRGNVSV TELVKSELLN ETDVQKLNQG KLTAKDIEDK
LKSYLCGSTC IAGIYDEVND RIMPFYQAMK EGLLMRGTTL ELLEAQAASG FIVDPVNNVF
LTVEEATKRG IIGKEFKSKL MSAERAVIGY TDPTTGKTIS LFQAIAKDLI EKGHGIRLLE
AQIASGGIID PVESHRIEVS VAYKRGYFDE EMNEILSYEG DDTKGFFDPN TKENLTYLQL
KERCITDKKT GLILLPLKDK KKAQQSKESR TNVLRKRRVV IVDPDTGLEM SVREAYHKDL
IDYETFLDLS EQECEWEEIT ITGSDGLARL VIVDRKTGTQ YDIQDCIDRA VIDQKMLDQY
RAGTLTLTEF ADQITSKTSS TEMTIAASSV DDMVTCSSPT QATPSSPTVR KRLSSISITV
SPPGMFDDQS PVAAIFDTET LEKITVTEGL KRGIVDTLTA QRLLEAQACT GGIINPATGD
RLSLEDALHQ SIIDESMAAK LKASQKAYIG FEDVKTKRKL SAAEAVKENW LPYEAGQRFL
EFQYLTGGLI EPHTGRRVSI EEAIRKGWLD GKGAQKLQET RNHQKNLTCP KTKLKISYKE
AMDSCMVEES NGMKMLQASS VSTKGISSPY NVSNPGSRSG SRAGSRTGSR SGSRRGSVDY
SSSYSYSFSS SSTTYS
//
