ID A0A3B5QMV7_XIPMA Unreviewed; 1440 AA.
AC A0A3B5QMV7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Nestin {ECO:0000313|Ensembl:ENSXMAP00000032363.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000032363.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000032363.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000032363.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR STRING; 8083.ENSXMAP00000032363; -.
DR Ensembl; ENSXMAT00000023254.1; ENSXMAP00000032363.1; ENSXMAG00000025410.1.
DR GeneTree; ENSGT00940000169377; -.
DR InParanoid; A0A3B5QMV7; -.
DR OMA; QASHMDE; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0019215; F:intermediate filament binding; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR031211; Nestin.
DR PANTHER; PTHR47051; NESTIN; 1.
DR PANTHER; PTHR47051:SF1; NESTIN; 1.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 90..401
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 462..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1020..1063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1256..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1420..1440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 157..244
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 278..372
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 615..629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..747
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1046
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1149..1183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1224..1244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1440 AA; 163204 MW; 35808943DDFEBC55 CRC64;
MSPAPSLNPA RKRYLFLLAV TPPDFTGRSL RNKETPHADS GLERRDRADC QIIIPLLPKE
TSFSKIYFFL TNMELHGVHK IFLPNHLGEE KQQMLNLNRR LETYLSWVKC LEEENEMLAN
EIKVFRHNNQ GTLTRRRGLE EELRQTRLEV DATWRERVLT EVEVQKLTEE IQALEMQRQM
EAEAKMLAKT KMEQSRKELE NEQRAQIWLR EKVNQLEHEM KFLIQTHEED VTHLEATLSQ
SRAEMLPNQI HRSKQTPDLL KMGHEFSQRA TRAWQEASES YQGQLVQLEE SLDQARSRLS
QVCLEKRESQ LKLQTLEKEI VSAQDVRLHL EKTVAQRSEE HCQEIQQLGK HLEELEVEKV
ELGQQIDHLL QENHSLMQMK MSLGLEVATY RALLDGEGLG RDAVLLNKPR SISIRDAVLS
PHGVKKNYPI QLSASLKTTY PSPGQGRTGS VITATQFLSR RPAALREPPK TSSKPAETAA
VKSATLESPY PKIVQNGAAE NFRPEEVHEK VTYAEPLSPP NEEEASNRMS EDEDKTVVER
VIESVVSHTA VLGLSREEPL NEKIGNQQST ALSPTSYDVR ITELPCNFSD ELLKDLAFEG
ETEEENVEHL RAQADGSTKV EHVQDETSDS ETEAMLEPTF ESRPSSPEFE CEPLESVFNR
NDESISNVDA VIMRQESSSS TVEVNERDDE DKLYPDGEEM DTWDSVIERK VSERIDDGVE
NEGNKQHAEP EEDISTKDPE ENRKVGQEGN MDFVLPQVDE GHHAIWELEH VPPPDTEEGG
DEEDSQNVSV SWRTELESDS YAQDNTLADT RPLIRYKSDD TDANTQASHI VESESSEGEQ
EKKAGEAGSG TWADGKPKTF GTMEDLCEEV EEETVDDDYN MGYTHVEDRD ADQGKKVSEY
DILLKDAEKV EEMVMSFVEG HSEEETEELT GATVHTNIDY DEELEIDRLV EQELENLSTD
SYSTHFGHEK VREDILEMNQ KSIKEMNEQE ITGNTTQSEN YESALTTAVI SKSLERQFFS
DSSPEVQLAS TLTEEEVKEQ KETEKAAGGS SSEIVKSEFE PATTITRDAS ERQLFSDPTV
EIPSANTQLV NEQKGTEKLI EETESSEPEM SANYEQLSST IVEDVALERQ LFSDSYVEIN
STNKLTEEDI HPINQEAVDN PETRKDDSEH NRVSHVDGTE NHSELKDFLS RSDMEDISII
EDPSSVLLVT ADSNPPQDVD APTEKTEALP KERSNVSQEH PTKDAEDFHK FLEDGETTEW
ENPENTTKES EMSDQIKHDL KNDNLHEISD KIIIHQEEPV EVSLDSALNE NDIFKVKDVK
DSSFHSHFTS DGKNDFWVSS LETGATYTPN DACNKSAEQT NHNQGFADNR DWGNLENPKV
INGNSKVDID LSGLDPTKEQ EQGNAEVKKV LCKNIVEGEM VHSEESDVEA ESWSSGEETA
//
