ID A0A3B5QRJ2_XIPMA Unreviewed; 1099 AA.
AC A0A3B5QRJ2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=AF4/FMR2 family member 4 {ECO:0000313|Ensembl:ENSXMAP00000033206.1};
GN Name=AFF4 {ECO:0000313|Ensembl:ENSXMAP00000033206.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000033206.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000033206.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000033206.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR AlphaFoldDB; A0A3B5QRJ2; -.
DR Ensembl; ENSXMAT00000023935.1; ENSXMAP00000033206.1; ENSXMAG00000001642.2.
DR GeneTree; ENSGT00950000182974; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF15; AF4_FMR2 FAMILY MEMBER 4; 1.
DR Pfam; PF05110; AF-4; 1.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 836..1097
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 970..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..545
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..748
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..820
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..839
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1099 AA; 119087 MW; AFEF03D611E28C86 CRC64;
MNREDRNVLR MKERERRNQE IQQGGGGGEA FPANSPLFPE PYKVASKADL LSNRIQSMLG
NYDEMKEPIG DTLPKLPGKP SNSSSSSEEK SGPPLFGGDQ RGVGSGGGSQ SSKWTPVGAP
PGGSSSQSQK RSGLSGGHGS QRNSGSSSGG SSSSQRGEVR EKKSSKHSGG SEHSKSHTSS
PAKGSLSSSS SHSRSSLSAE QHHPKYRNKS PRDREANWDS PSRVHTSFPS GQHSNQAFPP
SLVSKPSSML QKPTAYVRPM DGQETAEPKS SQAESYGGQS HSSTMGEVKT MGKASLTKLK
IPSQPVEGSG DANCVDEILK EMTQSWPPPL TAIHTPCKTE PSKFPFPTKD AHSFTSGHKR
GNSSKSSSSH QPKDSTMLKE DLIVSSSEDS DGEQESKNAS RNTSASNNSE AAEPSRDDSS
SHSGSESSSG SDSESESSTT DSEANERPRT ASPEPEQPVT NKWQLDNWFK NVPPKCKKEG
RDYSSKDSAP PPPSRDKGAE GGRGRQKSPA QSEGGTNPRI RVGKKQPKKS EKPPVVEEPK
GGLKVETEPA PEIPPLRPIA ATKGSRKPSI KKEPKSSPRP SAASVTTTTD KRKAKAPTKS
REILSTDSSS SDSEGNDSIP SSSQTPKYTE SIRTPVCVFS PVLSPLSDPE ERYPTRQPQQ
QVLLVKIDLS LLSRIPGRPY KEPAEIKVER EDSQDRESSK QSKSKRKHKT DDEGTKPESK
RFKPDDKTQS PHKTSSKESK RPLEKKEEPV PSPSISGPQR TPKSEHPSRK GTVNQPSTLL
SSGSTSKKAG SHGSKGSSTS KHKKGDDKGR STREGKVDEK ISTNQLAVPP LSTDGSRSQR
SKMVFEDRVH SADHYLQEAK TLKHNADALT NRFEKAVYYL DAVVSFIECG NALEKSAQEA
KSPFPMYAET VELIRYTMKL KSYMAPDATS ADKRLAVLCL KCQSLLYLRL FKLRKDSALK
YSKTLTEHLK NSLSNTQAPS PGMGNKAAGM PSPVSPKLSP GTAGSYSSVS SNSSASSSVT
IPQRIHQMAA SYVQVTSNFL YATEIWDQAE QVSKEQKDFF SELDKVMGPL IFNTSSMTEL
VRYTRQGLHW LRLDANLSH
//
