ID A0A3B5QT24_XIPMA Unreviewed; 1600 AA.
AC A0A3B5QT24;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1-like {ECO:0000313|Ensembl:ENSXMAP00000033691.1};
GN Name=MAGI1 {ECO:0000313|Ensembl:ENSXMAP00000033691.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000033691.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000033691.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000033691.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR STRING; 8083.ENSXMAP00000033691; -.
DR Ensembl; ENSXMAT00000021847.1; ENSXMAP00000033691.1; ENSXMAG00000016982.2.
DR GeneTree; ENSGT00940000155820; -.
DR InParanoid; A0A3B5QT24; -.
DR OMA; MGFGFRI; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 6.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.42.10; -; 6.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF77; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF16663; MAGI_u1; 1.
DR Pfam; PF16666; MAGI_u5; 1.
DR Pfam; PF00595; PDZ; 5.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 6.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 6.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 6.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
FT DOMAIN 17..100
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 104..184
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 296..345
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 372..405
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 483..552
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 652..730
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 834..916
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 995..1091
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1145..1227
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 225..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1108..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1227..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1310..1445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1457..1540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1562..1600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..794
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1108..1123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1273..1292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1344..1377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1393..1445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1466..1480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1502..1533
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1562..1581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1585..1600
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1600 AA; 176169 MW; 8E72E720BFB4DECF CRC64;
MSKVIQKKNH WITKVNECAV IRDENGELNV ELHGGAENGE FAYIGQIRED AVVYQDGKLS
EGELLLEVEG LSVSGLPLYD IYTVINCCKG PVRLKTVRQG HKLNKDLKHF LSLRFQKTSP
DHELQKTIRA NLYRHAVPCT TRPPRDGEVP GLDYNFLSVE DFLQLEESGT LLEVGTYEGN
YYGTPKPPRQ PIIGTVTLSD EGSHPSTPKR TKSYHDMQKV HVVPADDDDD DQATEMNNSF
TGNPNDQDES RSGILRPYPV RDNALPCGLN NAATSTAESG QQTLAEPQVS PEDPLGPLPE
NWEMAYTENG ELYFIDTAKT LHQDMAVCFQ SFHNTKTTSW LDPRCRDKAP RPLEECDDDE
EGIHTEDLES DLELPPGWER IDDPVYGVYY VDHINRKTQY ENPVLEARRQ KILEQQQPPQ
PPEEWIEEHS SAAAPLASYA PNHLETYRDP QVPPALPPGP VGVKRGKPFF TRNPAELKGT
FINTKLKKSR RGFGFTVVGG DEPDEFLQIK SLVLDGPAAV DGKMETGDVI VSVNDTIVLG
YTHAQVVKIF QSIPIGSMVD LSLCRGYPLP FDPDDPNTSL VTSVAILDKE PIIVNGQETF
DAPTNQAGPI NGMREPRPHS PLAEVASNGS HGYSSDVVTL ASAIATQPEL ITIHMEKGDK
GFGFTIADSL TGGGQRVKQI VDYPRCRGLK EGDILMEVNK RNVQNMSHNQ VVDLLSKCPR
GSEVTMLVQR GVVPAKRSPK LVQLERKDSQ SSSQHSVCSH RSAHTDSPSH PPSAMPSEAV
VPTPAAPTQP LPVLPLQDPA DGTLTLQKKP DPFKIWAQSR SMYESRLPDC QEQDIFLWRK
DTGFGFRILG GNEPGEPIYI GHIVKYGAAD EDGRLRSGDE LICVDGTAVV GKSHQLVVQL
MQQAAKQGHV NLTVRRKTPG YGVSKGEGDV PPSPASSHHS STQAPSLTEG KRTPQGSQNS
LNTVSSGSGS TSGIGSGGGG GSGSAVIPAS LQPYDVEIQR GENEGFGFVI VSSVSRPDAG
TTFAGNACVA MPHKIGRIIE GSPADRCGKL KVGDRILAVN GCSITNKSHS DIVNLIKEAG
NTVSLRIIPG DESSNASLLT NAEKIATITT THTPQTTELR NHSKSKGAPP PPPSQTQMQD
AEYYSVDLER DSKGFGFSLR GGREYNMDLY VLRLAEDGAA VRNGKMRVGD EILEINGEST
KNMKHSRAIE LIKNGGRRAR LVLKRGDGSV PEYDGSSDGH PPAPRAQNTP EVRTLPPKSR
YHTSLESSYP PDFHKPSRLE EAARGRGMDK NRDWAGSDLM DFHGRQFNPH HHHTWNNSHS
QSTLRQESPD NSNDSSAGNK KSQGRKVKKS ESESGISKLL KTLRKDNSGK KAAAAAEKLR
GQELSSSSST LDRRFQLHRR GSLDRSPTRK RNSSPDRRRA KSMDRRAERA HRDHTPEKEY
DDGGFLSVTP ERKLFERKHL KESQVAGRVS ESSTPDRVNN RGDSLPRGRS YEKATKNGNL
LRDSSSERKE ERNRMNGTME RRYRSEQDSS PDSNYSRDEL NYAAAPRLKD YYSMMKNNAA
HNNATYNKTG PINNAGGRSS NQIPEPKRRL YKENSKDLSI
//
