ID A0A3B5QTB6_XIPMA Unreviewed; 1349 AA.
AC A0A3B5QTB6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Adhesion G protein-coupled receptor A3 {ECO:0000313|Ensembl:ENSXMAP00000033771.1};
GN Name=ADGRA3 {ECO:0000313|Ensembl:ENSXMAP00000033771.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000033771.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000033771.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000033771.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR RefSeq; XP_014325974.1; XM_014470488.1.
DR STRING; 8083.ENSXMAP00000033771; -.
DR Ensembl; ENSXMAT00000039910.1; ENSXMAP00000033771.1; ENSXMAG00000007771.2.
DR GeneID; 102224749; -.
DR KEGG; xma:102224749; -.
DR CTD; 166647; -.
DR GeneTree; ENSGT00940000157235; -.
DR InParanoid; A0A3B5QTB6; -.
DR OMA; CQQHYQH; -.
DR OrthoDB; 2900279at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45930:SF2; ADHESION G PROTEIN-COUPLED RECEPTOR A3; 1.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1349
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017337003"
FT TRANSMEM 728..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..782
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 794..817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 843..863
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 883..906
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 982..1003
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1009..1030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 225..323
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 306..401
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 725..905
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 917..946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1082..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1164..1188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1235..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1292..1306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1349 AA; 149095 MW; 442165099888F4EC CRC64;
MRLDWLQLVV VLLLSGLRGS AVPFACKTSD EGPKSGGKSP ASDRKVVCSN MELHQVLPAD
SFPNRTVILI LNNNKIQELR NGAFSGLSTL EKLDLRNNLI SHIEPGAFLG LKTLKKLDLS
NNSISCLNGD VFKGLESLSR LILSGNMFSS LAQGMFDRLV SLKALEFQTP YLLCDCNLLW
LLRWIKDRNV SVKNTKCSYP QSLQGQLITS LRPELLTCDA PLELPSFQLT PSQRQVVFQG
DSLPFQCQAS LVAEDMQVLW YQNGRMVKPD ATQGIFIEKR IVQNCSLIAS ALTISNIQPG
FTGNWECRVR TSRGNTTRAV HIVVLQSSAK YCAPERISNN KGEFRWPRTL AGIKAYLPCN
LPTSSARAYS GILSEERQAW RHCSPEGLWT EGDYSQCQFQ KEVTRGLYVI NQMPLNETNV
VIKAQSLLVY TIDAANLSDK MDIIFMAEMI EKLGEFVEKF KDLGEVMVNM ASNLMLADER
VLWMAQREAM ACSRIIASLQ KISAYRLSTA QAFSLTSPNI ALEAHTVRVN DWNGMTCILF
QRPSPERLPG HDRQLTFKCN TTSSFASGLY KSTIVEASLQ LPRSLFSQAA TPGQTDDNVY
KLYLLGFRNG KFFPSTWNTS LLADGGRKRS VATPVIMAKM DGISLRSLKT PINITLRRFA
RGSDAVSARW NFSLAGDQGG WRSEGCRILE NHDNFTTMSC NSLGNYGLLM DLNTVEQFSP
SFQPLHPVIY ATSVVLLLCL FTIIISYIYH YRSVCVSRKF WHMLVNLCFH MALTCGIFVG
GINQTRYASV CQAVGILLHY STLATALWVG VTARNIYKQL TRKAKRYEEL DEPPPPPRPM
LRFYLIGGGI PIIVCGITAA ANIKNYGSQR YSPYCWMAWE PSIGAFYGPA GFIVFVDCMY
FLSILLQVHR HPERRYELKE SSEEQQHLAS AGSEVTPEGP SSLSHPLTVQ LQPNEALSSV
GSAPHAVPLS ALENEHTFTA QLIGAVGALG LYSGLWVFGA MAVSQDHPFD MAFTCLFGLT
ALALGAFMMA HHCVNRQDMR RFWLQVYCSR RRVYSAQEEV LLPQTGVAVM VTAEKADGKS
VKCSHSSADS SYTNRSAPTS IRNSGHGSKL TNLHAEAAQC KAASAPATAN GTAVLDSSLT
EHSLDNEIKM HVAPVEVQFR PLSNISNPAA NGSTSRHQKN RARAHRASRL TVLREYAYDV
PTSVEGSVQS APSRRHHYYD MAARNSRRAA YMAYRERHQS QLQQDSSDSA SLPRRSRFSE
KGSGTLLENG TAVSVEAEQA APAGSPAASK DTVLPPGSSE SENKSSKWYG LNLVTQNNGT
LRKNGQAMPL VNGDGACIKT GLWKHETTV
//
