ID   A0A3B5QWF8_XIPMA        Unreviewed;       409 AA.
AC   A0A3B5QWF8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Endoplasmic reticulum protein 44 {ECO:0000313|Ensembl:ENSXMAP00000035192.1};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000035192.1, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000035192.1}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000035192.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_005810628.2; XM_005810571.2.
DR   AlphaFoldDB; A0A3B5QWF8; -.
DR   STRING; 8083.ENSXMAP00000035192; -.
DR   Ensembl; ENSXMAT00000027641.1; ENSXMAP00000035192.1; ENSXMAG00000026085.1.
DR   GeneID; 102220894; -.
DR   KEGG; xma:102220894; -.
DR   CTD; 23071; -.
DR   GeneTree; ENSGT00930000151031; -.
DR   InParanoid; A0A3B5QWF8; -.
DR   OMA; DWCRFSN; -.
DR   OrthoDB; 90290at2759; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   GO; GO:0010882; P:regulation of cardiac muscle contraction by calcium ion signaling; IEA:Ensembl.
DR   CDD; cd02996; PDI_a_ERp44; 1.
DR   CDD; cd03072; PDI_b'_ERp44; 1.
DR   CDD; cd03070; PDI_b_ERp44; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 3.
DR   InterPro; IPR041862; ERp44_PDI_b.
DR   InterPro; IPR041870; ERp44_PDI_b.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR46295; ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44; 1.
DR   PANTHER; PTHR46295:SF1; ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44; 1.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   Pfam; PF13848; Thioredoxin_6; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 3.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           31..409
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017350045"
FT   DOMAIN          20..142
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   REGION          359..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   409 AA;  46733 MW;  C8AAD5582F7A6D36 CRC64;
     MKLFAISPSL DIRFAAVILL VMGLSTPGKA EIISLDSSNI DDVLNNAGVA LVNFYADWCR
     FSQMLHPIFE EASNIVRDEF PDTKQVVFAR VDCDQHSDIA QRYRITKYPT LKLFRNGMMM
     KREYRGQRSV TAIADFIRQQ QVDPVKEIHS MEEVNTIDRS KRNIIGYFEQ KDSDNYRTYE
     KVANILRDDC TFSAAFGAVS ASQRFSGDSV LYKPVGEGAP DLVYLGSLTN FDLTYTWAQD
     KCVPLVREIT FENGEELTEE GLPFLILFHL KEDSESLEKF QNEVTRQLIS EKGSINFLHA
     DCDKFRHPLL HIQKTPADCP VIAIDSFRHM YVFPDFKDLT IPAKLKQFVL DLHSGKLHRE
     FHHGPDPTDS TPGQEAEKEV ASSPPESSFQ KLAPSETRYT ILRRDRDEL
//