ID A0A3B5QWN0_XIPMA Unreviewed; 767 AA.
AC A0A3B5QWN0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=FCH and double SH3 domains 2 {ECO:0000313|Ensembl:ENSXMAP00000035668.1};
GN Name=FCHSD2 {ECO:0000313|Ensembl:ENSXMAP00000035668.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000035668.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000035668.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000035668.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005809081.1; XM_005809024.1.
DR AlphaFoldDB; A0A3B5QWN0; -.
DR Ensembl; ENSXMAT00000040878.1; ENSXMAP00000035668.1; ENSXMAG00000018119.2.
DR GeneID; 102222287; -.
DR KEGG; xma:102222287; -.
DR CTD; 9873; -.
DR GeneTree; ENSGT00510000046732; -.
DR OrthoDB; 3674259at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR CDD; cd11894; SH3_FCHSD2_2; 1.
DR CDD; cd11761; SH3_FCHSD_1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR035556; FCHSD2_SH3_2.
DR InterPro; IPR035460; FCHSD_SH3_1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735:SF11; F-BAR AND DOUBLE SH3 DOMAINS PROTEIN 2; 1.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 8..283
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 467..528
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 565..627
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 628..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..680
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 86836 MW; 098EA84B764E5209 CRC64;
MQPPPRKVKV TQELKNTHTE QMTRLHFKHQ TECDLLEDMR SYSLKKGQLE RDYAQALQKL
ASQYLKRDWP GISPDDQRTD YRNVYAVWRA YLEGTVQVSQ SRLNVCDNYK SQISEPAKTV
RLYKEQQLKK TIDQLSGIQA ELQESVKELA KAKKKYYDCE QVAHAVREKA DIEAKSKLGL
FQSRISLQKA SVKLKAKRSD CNSKATQARN DYLLTLAAAN AHHDRYYHTD LLHCIQDLDG
RIYEHVKDYL VALCRTELEA SQATHSTFQF LLEKSSRIIQ EFNQQLFMQE NPVFHKAHDF
QFQASEYDMS RQLESESGTT EEHSLNKEAR KWATRVAREH KNIIHCKRSL EECESHGLPP
TEQGRLDLEL KIEDTKEIMR KAETIKLKAE ARLDLLRQVG VAVDTWLKSA MNQVMEELEN
ERWATYTTHD PSLSGTVDLE REEGEECEEN MEVFDDSSSS PSGTLRNYPL TCKVLYSYKA
SQPDELTIDE QEMLEVIEDG DMEDWVKARN KTGQVGYVPE KYLQFPTSNS LLSMLQSLAT
LDARSHTSSN STEPELHSGC INGDTNTAYV RALYDYEGQA DEELSFSEGA VIRLLNRDTQ
TDDGFWEGEL NGRVGVFPSV LVEDLTENGE TSGGALNDPQ ISPSSKLPSS LPPLPLYEQP
PISPFTSPET STPPPLPRSP STALNGEHKL PLPASSHKGQ LSSHNQSSGR SPVSPGFPQT
QPLRFTAEGG GPGKLRPVRA APPPPKQQPR RPHEKSDKTE EVEITLV
//
