ID   A0A3B5QX43_XIPMA        Unreviewed;       945 AA.
AC   A0A3B5QX43;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=B30.2/SPRY domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000035759.1, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000035759.1}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000035759.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B5QX43; -.
DR   Ensembl; ENSXMAT00000042255.1; ENSXMAP00000035759.1; ENSXMAG00000026463.1.
DR   GeneTree; ENSGT01100000263487; -.
DR   InParanoid; A0A3B5QX43; -.
DR   OMA; RSRESWC; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd16040; SPRY_PRY_SNTX; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR029495; NACHT-assoc.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR   Pfam; PF14484; FISNA; 1.
DR   Pfam; PF13516; LRR_6; 2.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF13765; PRY; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM01288; FISNA; 1.
DR   SMART; SM00368; LRR_RI; 3.
DR   SMART; SM00589; PRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS51450; LRR; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT   DOMAIN          120..252
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   DOMAIN          749..943
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
SQ   SEQUENCE   945 AA;  107427 MW;  9BBB427ECE65A186 CRC64;
     MTMNIRKDFV PLYITSEEII LISFFCIHLE SFTTCQQTLK SNMKKKFQSV FEGITKSGNQ
     SFLNEIYTEL YITEGGSEEV NDEHEVRQIE TMSWKPERAE TAIRHGDIFI PSPEREEPIK
     TVMTTGMAGI GKTVLTQKFT LDWAEDQTNQ DIQFTFPFTF RELNLLKDEQ FSLVELVHHF
     FSETKGILKF EELKVVFIFD GLDESRFPLD FYNNEILMDV TKSTSVDVLL TNLISGKLLP
     KAHLWITTRP AAANKIPAEF IGMMTEIRGF TDPQKDMYFT KRFKSKKQAS LVISHVKKSR
     SLHIMCHIPI FCWITAKVVE DMLNKKDGEE LPKTLTEMYI HFLVVQAKLK VIKYDGGAET
     DSNWSPENQK MIKSLGKLAF DQLQKRNLIF YESDLAECGI DIRAASTYSG VFTQIFREER
     GLYQIKLFCF VHLSVQEFLA ALHVHLTFIK SGVNLLVKGK MKSKEIEKRN HESSETEMYK
     SAVDMALESP DGHLDLFLRF LLGLSLETNK RRLRGFVAQT EESLAINKDT AQYIKEKLNH
     HGIEKSINLF HCLSELNDQS LVEEIQQSLC TGSLSAHQLS PAQWSALHYI LLSSDKGLEI
     FDLKKYCASE EALQRLTDGV SFKKVPNNNN TITLNCLCLF RLSGCNLSEK SCEALSSFIS
     LTTSSLKDLD LSNNDLTDSG VKLLCEGLMS PNCELEILRL SGCLITEEGC AALASALTVS
     SSHLKELDLS YNNPGEAGMK SLEAILKNPK NYTSVTALCL FCPSDSCPLT VDLNTVNRFL
     KLSDENRKVT RVEEEQPYPD HPDRFDLYQL LCTDGLTGRC YWEVEWGGKV YVSLSYRGIK
     RKGESDDSWF GFNNNSWCLV CSNDGYTVWH NSKKVLIPSS SSISGRVAVY VDCPAGTLSF
     YRVSSETLIH IYTFNTKFTE PLYPGFDQIQ QPDVQFDLRK YCSTI
//