ID A0A3B5QXR6_XIPMA Unreviewed; 384 AA.
AC A0A3B5QXR6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=EGF-like domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000036078.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000036078.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000036078.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; A0A3B5QXR6; -.
DR Ensembl; ENSXMAT00000038750.1; ENSXMAP00000036078.1; ENSXMAG00000025262.1.
DR GeneTree; ENSGT00940000165769; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00112; LDLa; 6.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 7.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00192; LDLa; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 7.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 7.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 85..121
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 287..322
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 323..361
FT /note="EGF-like calcium-binding"
FT /evidence="ECO:0000259|SMART:SM00179"
FT DOMAIN 326..361
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DISULFID 6..18
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 13..31
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 25..40
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 86..98
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 93..111
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 105..120
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 130..148
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 142..157
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 162..174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 169..187
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 181..196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 201..213
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 208..226
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 220..235
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 384 AA; 42144 MW; 99A90EE962BF04AB CRC64;
MLYFICASDE FQCRNGQCIN KAWRCDGTKD CTDDSDELNC PPPSCSSQEF KCVTSGECIS
LGFVCDGEED CVDGSDEQRT CDGRTCRPDQ FTCQEGQCIP SKYRCDRVTD CVDSTDEKNC
NYPQCTQKTC ANGACYNNSQ HCNGLQDCRD GSDETNCTTH HCPIHQFECR NGFCVPLAFV
CDHWDDCGDN SDEQDCEYPT CKGNEFTCSS GRCIPQNWVC DKSNDCGDFS DESGCDSDSR
DCYPGEWGCP GSTACIPVDK VCDGKPDCPG ATDETNTTAH QTCGLDRCSA LSCEYLCHPS
PQGGTCYCPD GFIVANDSRS CVDYDDCNIW GICDQLCEDR PGTHHCSCAD GFFLEQGHVC
KANVSGTLTS DLDLTLHTVK LFDI
//
