ID A0A3B5R0C1_XIPMA Unreviewed; 466 AA.
AC A0A3B5R0C1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Phosphatidylinositol 3-kinase regulatory subunit gamma-like {ECO:0000313|Ensembl:ENSXMAP00000036667.1};
GN Name=PIK3R3 {ECO:0000313|Ensembl:ENSXMAP00000036667.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000036667.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000036667.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000036667.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B5R0C1; -.
DR STRING; 8083.ENSXMAP00000036667; -.
DR Ensembl; ENSXMAT00000030889.1; ENSXMAP00000036667.1; ENSXMAG00000021498.1.
DR GeneTree; ENSGT00940000156259; -.
DR InParanoid; A0A3B5R0C1; -.
DR OMA; DWLGIHN; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS50001; SH2; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 47..142
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 337..431
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 434..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 54078 MW; A642C8B246049ECC CRC64;
MVYPPEGLFY IEMDQAPPAL PPRSTKPTMN NNNCLSPPVC SLQDAEWYWG DITRDEVNEK
LRDTPDGSFL VRDASTKLQG DFTLTLRKDG HNKLIKIYHR DGKYGFSDPF TFTSVVELIW
YYQHHSLVEY NAMLDLMLMH PVSRFQQVKE DSVDVAGRKL KEVHNQYQEK SKEFDRLYEA
FTKTSQEIQM KRTAIEAFNE AMLIFEEQCR EQERYGEEFE RNSLSEGADN DLESFLINYE
KLKCRLGEIY DSKLHLEDDL RTQVEDYRET DRKINNLRPD LIQLRNIRDL YLNWLNHKGV
RQKRINDWLG IHNDSLDDTY VLKGDEKNLP HQDEASWFVG ELSRTQAEEM LQGKVSGTFL
IRESSKQGCY ACSVVVSEEV KHCMIYSTSH GYGFAEPYDA HCSLKDLVLH YHLHSLAQHN
DALDVRLLHP VHAKAADPAS QHSDEHKLLQ TPKHVPPGLP PAAPEM
//
